Keflin

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Cefalotin

Available from:

Aspen Pharmacare Australia Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

KEFLIN
®
 NEUTRAL

_cefalotin sodium_
CONSUMER MEDICINE INFORMATION (CMI)

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about KEFLIN Neutral. It
does not contain all the available
information and does not take the
place of talking to your doctor.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
BEING GIVEN THIS MEDICINE, TALK TO
YOUR DOCTOR.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT KEFLIN NEUTRAL
IS USED FOR
KEFLIN Neutral contains cefalotin
(as cefalotin sodium) as the active
ingredient. It belongs to a group of
medicines called cephalosporins.
KEFLIN Neutral is an antibiotic used
to treat serious infections in different
parts of the body caused by bacteria.
It is also used to prevent possible
infections before, during and after
surgery.
KEFLIN Neutral works by killing the
bacteria that are causing the
infection.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY KEFLIN
NEUTRAL HAS BEEN PRESCRIBED FOR
YOU.
Your doctor may have prescribed it
for another purpose.
This medicine is available only with
a doctor's prescription.
There is no evidence that it is
addictive.
BEFORE YOU ARE GIVEN IT
_WHEN YOU MUST NOT BE GIVEN_
_IT_
YOU MUST NOT BE GIVEN KEFLIN
NEUTRAL IF YOU HAVE HAD AN ALLERGIC
REACTION TO:
•
cefalotin
•
sodium bicarbonate.
Signs of an allergic reaction may
include shortness of breath, wheezing
or difficulty in breathing; swelling of
the face, lips, tongue or any other
parts of the body; rash, itching or
hives on the skin.
YOU MUST NOT BE GIVEN THIS
MEDICINE IF YOU HAVE HAD A SERIOUS
ALLERGIC REACTION TO ANY OTHER
CEPHALOSPORIN ANTIBIOTIC OR
PENICILLIN ANTIBIOTIC.
If you are allergic to a cephalosporin
or a penicillin, you may have an
increased chance of being allergic to
KEFLIN Neutral.
YOU MUST NOT BE GIVEN THIS
MEDICINE AFTER THE EXPIRY DATE HAS
PASSED OR IF THE PACKAGING IS TORN
OR SHOWS SIGNS

Summary of Product characteristics

1 

PRODUCT INFORMATION 

KEFLIN
®

CEFALOTIN SODIUM FOR INJECTION 
NEUTRAL 

DESCRIPTION 

KEFLIN (cefalotin sodium), Neutral, is a semisynthetic cephalosporin
antibiotic for 
parenteral use.  It is the sodium salt of 7-(thiophene-2-acetamido)
cephalosporanic 
acid.  Sodium bicarbonate has been added to result in reconstituted
solutions having 
a pH ranging between 6 and 8.5.  The total sodium content is
approximately 63 mg 
(2.8 mEq. sodium ion) per g of KEFLIN Neutral. 

MICROBIOLOGY/PHARMACOLOGY 

Microbiology - The in-vitro bactericidal action of cefalotin results
from inhibition of 
cell-wall synthesis.  In general, cefalotin has higher activity
against Gram positive 
than Gram negative organisms, the latter varying greatly in their
sensitivity to the 
drug.   The range of antibiotic concentrations at which bacteria are
inhibited may 
vary substantially according to the isolate, therefore susceptibility
testing is highly 
desirable.  KEFLIN is usually active against the following organisms
in-vitro:  

Beta-haemolytic and other streptococci (most strains of enterococci,
e.g. 
_Streptococcus faecalis _are resistant). 

Staphylococci, including coagulase-positive, coagulase-negative, and 
penicillinase-producing strains. Methicillin-resistant staphylococci
are 
resistant. 

_Streptococcus pneumoniae_ 
_ Haemophilus _
_influenzae_ 
_ Escherichia _
_coli_ 
_ Klebsiella_ 
_ Proteus _
_mirabilis_ 

NOTE:  _Pseudomonas _organisms are resistant to KEFLIN, as are most
indole- 
producing _Proteus _species and motile _Enterobacter _species. 

Susceptibility Plate Tests - If the Bauer-Kirby-Sherris-Turck method
of disc 
susceptibility testing is used, a disc containing 30 mcg cefalotin
should give a zone of 
over 17 mm when tested against a cefalotin-susceptible bacterial  
strain, and a zone of over 14 mm with an organism of intermediate
susceptibility. 

2 
Human Pharmacology - KEFLIN is not absorbed significa