KETAJECT ketamine hydrochloride injection solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

KETAMINE HYDROCHLORIDE (UNII: O18YUO0I83) (KETAMINE - UNII:690G0D6V8H)

Available from:

Clipper Distributing Company, LLC

INN (International Name):

KETAMINE HYDROCHLORIDE

Composition:

KETAMINE 100 mg in 1 mL

Prescription type:

PRESCRIPTION

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

KETAJECT- KETAMINE HYDROCHLORIDE INJECTION, SOLUTION
CLIPPER DISTRIBUTING COMPANY, LLC
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KETAJECT
KETAMINE HYDROCHLORIDE INJECTION, USP
ANADA 200-257, APPROVED BY FDA
VETERINARY INJECTION FOR INTRAMUSCULAR USE IN CATS AND SUBHUMAN
PRIMATES ONLY
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
Ketaject (ketamine hydrochloride injection) is a rapid-acting,
nonnarcotic, nonbarbiturate agent for
anesthetic use in cats and for restraint in subhuman primates. It is
chemically designated _dl _2-(o-
chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride and is
supplied as a slightly acid (pH 3.5
to 5.5) solution for intramuscular injection in a concentration
containing the equivalent of 100 mg
ketamine base per milliliter and contains not more than 0.1 mg/mL
benzethonium chloride as a
preservative.
ACTION
Ketaject is a rapid-acting agent whose pharmacological action is
characterized by profound analgesia,
normal pharyngeal-laryngeal reflexes, mild cardiac stimulation and
respiratory depression. Skeletal
muscle tone is variable and may be normal, enhanced or diminished. The
anesthetic state produced does
not fit into the conventional classification of stages of anesthesia,
but instead Ketaject produces a state
of unconsciousness which has been termed “dissociative” anesthesia
in that it appears to selectively
interrupt association pathways to the brain before producing
somesthetic sensory blockade.
In contrast to other anesthetics, protective reflexes, such as
coughing and swallowing are maintained
under Ketaject anesthesia. The degree of muscle tone is dependent upon
level of dose; therefore,
variations in body temperature may occur. At low dosage levels there
may be an increase in muscle tone
and a concomitant slight increase in body temperature. However, at
high dosage levels there is some
diminution in muscle tone and a resultant decrease in body
temperature, to the point where supplemental
heat may be advisable.
In cats, there is usually some tr