Lidocaine-Liqvo with epinephrine solution for injection

Country: Armenia

Language: English

Source: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում

Active ingredient:

lidocaine (lidocaine hydrochloride), epinephrine

Available from:

Liqvor CJSC

ATC code:

N01BB52

INN (International Name):

lidocaine (lidocaine hydrochloride), epinephrine

Dosage:

20mg/ml+ 0,01mg/ml

Pharmaceutical form:

solution for injection

Units in package:

(1) and (10) glass vial 20ml

Prescription type:

Prescription

Authorization status:

Registered

Authorization date:

2019-02-08

Patient Information leaflet

INSTRUCTIONS FOR MEDICAL USE
LIDOCAINE-LIQVO WITH EPINEPHRINE
1 % and 2 % solution for injection
REGISTRATION NUMBER: __________________
TRADE NAME: Lidocaine-Liqvo with epinephrine
INTERNATIONAL NONPROPRIETARY NAME: Lidocaine, Epinephrine.
PHARMACEUTICAL FORM: Solution for injection.
STRENGTH: 1 % and 2 % with epinephrine 1:100000
COMPOSITION: _ active ingredients_: lidocaine hydrochloride – 10.0
mg or 20.0 mg, epinephrine
hydrotartrate equivalent to epinephrine – 0.01 mg; _inactive
ingredients_: sodium chloride – 7.0 mg,
sodium metabisulfite – 0.5 mg, citric acid – 0.2 mg, benzalkonium
chloride – 0.05 mg, water for
injection – up to 1.0 ml.
DESCRIPTION: Clear, colorless or slightly yellowish solution.
PHARMACOTHERAPEUTICAL GROUP: Local anesthetic.
CODE ATC: N01BB52
PHARMACOLOGICAL EFFECT
_PHARMACODYNAMICS _
Lidocaine is a local anaesthetic of the amide type. It causes all
types of local anesthesia: terminal,
infiltration, conduction. The local anesthetic action consists in
neuronal membrane stabilization by
reducing its penetration for sodium ions, which prevents action
potential occurrence and impulse
conduction. It rapidly hydrolyzes in a slightly alkaline media of
tissues and after a short latent
period acts within 60-90 minutes. Anesthetic activity decreases with
tissue acidosis.
Epinephrine - adrenoceptor agonist, constricts blood vessels and
prolongs lidocaine action.
_PHARMACOKINETICS _
Lidocaine is readily absorbed from the gastrointestinal tract, from
mucous membranes and through
damaged skin also in case of intramuscular administration.
The elimination half-life is 2 hours.
Lidocaine is metabolized in liver with formation of two
pharmacologically active metabolites. It_ _
eliminates with urine: approximately 90% of dose is excreted in the
form of metabolites and less
than 10% - unchanged.
Lidocaine crosses the blood-brain and placental barriers.
_ _
_ _
INDICATIONS FOR USE
All types of local anesthesia (infiltration and conduction anesthesia,
peripheral nerve blocks) in
dentistry, ophtha