NEURO-B TABLET

Summary of Product characteristics

                                NEURO-B TABLET
Each tablet contains:- Thiamine mononitrate 100mg
Vitamin B6 200mg
Vitamin B12
200mcg
Avicel
Magnesium Stearate
PVP
Starch
PHARMACOLOGICAL ACTION:
Thiamine
is
required
for
carbohydrate
metabolism.
Thiamine
combines
with
adenosine triphosphate to form thiamine diphosphate which is the
coenzyme in
carbohydrate
metabolism
and
transketolation
reactions.
The
organ
systems
principally affected by thiamine deficiency are the peripheral nervous
system,
cardiovascular system, and G.I. tract.
Vitamin B6 is required for amino acids metabolism; the vitamin is also
involved in
carbohydrate and lipid metabolism. It is converted to the active forms
of the vitamin,
pyridoxal phosphate and pyridoxamine phosphate, which acts as coenzyme
in a wide
variety of intermediary metabolism. Pyridoxine appears to be essential
in the
synthesis of GABA within the CNS and in the synthesis of heme.
Vitamin B12 is required for nucleoprotein and myelin synthesis, cell
reproduction,
normal growth, and the maintenance of normal erythropoiesis. Vitamin
B12 is
converted to coenzyme B12 in tissues. Through a variety of reactions,
vitamin B12 is
associated with fat and carbohydrate metabolism and protein synthesis.
INDICATION:
It is indicated in treatment of polyneuritis, neuralgia and diabetic
neuropathy.
DOSAGE:
Oral administration.
Adults: One tablet three times daily to be taken before or during
meals.
CONTRAINDICATIONS:
It
is
contraindicated
in
patients
known
to
be
hypersensitive
to
any
of
the
components. Cyanocobalamin should not be used in patients with early
Leber’s
disease (hereditary optic nerve atrophy). It is also contraindicated
in patients who
are hypersensitive to cobalt.
ADVERSE EFFECTS/SIDE EFFECTS:
The adverse reactions reported were nausea, headache, paraesthesia,
somnolence,
and urticaria. Long-term administration of large doses of vitamin B6
(pyridoxine) is
associated with the development of severe peripheral neuropathies.
Therefore,
regular monitoring is recommended under long-term treatment.
PREGNANCY AND LACTATI
                                
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