Natrilix SR

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Indapamide hemihydrate

Available from:

Servier Laboratories (Australia) Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

NATRILIX SR

_Sustained Release tablets containing indapamide (pronounced
in-dap-a-mide)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Natrilix SR. It does
not contain all the available
information about this medicine.
Reading this leaflet does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Natrilix SR
against the expected benefits for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT NATRILIX SR IS
The name of your medicine is
Natrilix SR. The medicine releases
the active ingredient indapamide
progressively over 24 hours.
Indapamide belongs to a group of
medicines called chlorosulphamoyl
diuretics (a type of "fluid" or "water"
tablet).
WHAT NATRILIX SR IS
USED FOR
YOU HAVE BEEN PRESCRIBED NATRILIX
SR FOR HIGH BLOOD PRESSURE.
Natrilix SR is available only with a
doctor's prescription.
There is no evidence that Natrilix SR
is addictive.
_WHY NATRILIX SR IS USED FOR_
_HIGH BLOOD PRESSURE_
Everyone has blood pressure. This
pressure helps to circulate blood all
around the body. Your blood
pressure may be different at different
times of the day, depending on how
busy or stressed you are.
You have high blood pressure (also
known as hypertension) when your
blood pressure stays higher than is
needed, even when you are calm and
relaxed.
If high blood pressure is not treated it
can lead to serious health problems.
You may feel fine and have no
symptoms, but eventually it can
cause stroke, heart disease and
kidney failure.
Natrilix SR helps to lower your blood
pressure.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY NATRILIX SR
HAS BEEN PRESCRIBED FOR YOU.
BEFORE YOU TAKE
NATRILIX SR
There are some people who should
not take Natrilix SR. Please read the
lists below. If you think any of these
situations apply to you, or you have
any questio

Summary of Product characteristics

NATRILIX
_® _
SR – PRODUCT INFORMATION 

1 (10) 

Version 5 

PRODUCT INFORMATION 

NAME OF THE MEDICINE 
_ _
_NATRILIX_
_®_
_ SR _
Indapamide hemihydrate 1.5mg (sustained release) 

_Chemical structure_:  C
16
H
16
ClN
3
O
3
S, ½ H
2
O 

_ _
_CAS Registry Number_: 26 807-65-8 

DESCRIPTION 

Indapamide hemihydrate (4-chloro-N(2-methyl-1-indolinyl)-3-sulphamoyl benzamide 
hemihydrate) is a non thiazide indole derivative
of chlorosulphonamide.  The active ingredient is a 
racemic mixture.  Indapamide is a white crystalline
lipophilic powder, soluble in methanol, 
ethanol, acetic acid and ethyl acetate, very slightly soluble
in ether, chloroform and benzene and 
practically insoluble in water. 

_Molecular Weight_: 374.85 (Indapamide hemihydrate) 

_Melting point:_ approximately 185°C 

_Excipients: _
Silica - colloidal anhydrous, glycerol, hypromellose, lactose, macrogol 6000, magnesium stearate, 
povidone, titanium dioxide. 

PHARMACOLOGY 

MECHANISM OF ACTION 

Indapamide is an oral antihypertensive agent.  The
mechanism whereby indapamide exerts its 
antihypertensive action has not been completely elucidated; both vascular and renal actions have 
been implicated.  The possible
beneficial pharmacological effects of indapamide in the
treatment 
of hypertension include a reduction in cardiac hypertrophy and a
reduction in the thickening of 
arterial walls, a prevention of the accumulation of the
embryonic isoform of fibronectin in coronary 
vessels, free radical scavenging leading to stimulation
of vasodilator eicosanoid formation, and 
interaction with renal carbonic anhydrase. 

The renal effects of NATRILIX SR (sustained release film-coated
tablet containing 1.5mg of 
indapamide hemihydrate) are minimal and the antihypertensive
effect of indapamide has been 
attributed to a
reduction�