Natrilix

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Indapamide hemihydrate

Available from:

Servier Laboratories (Australia) Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

NATRILIX

_indapamide (pronounced ind-ap-a-mide)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Natrilix. It does not
contain all the available information
about this medicine. Reading this
leaflet does not take the place of
talking to your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Natrilix
against the expected benefits for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT NATRILIX IS
The name of your medicine is
Natrilix. Natrilix contains the active
ingredient indapamide which belongs
to a group of medicines called
chlorosulphamoyl diuretics (a type of
"fluid" or "water" tablet).
WHAT NATRILIX IS USED
FOR
YOU HAVE BEEN PRESCRIBED NATRILIX
SR FOR HIGH BLOOD PRESSURE.
Natrilix is available only with a
doctor's prescription.
There is no evidence that Natrilix is
addictive.
_WHY NATRILIX IS USED FOR HIGH_
_BLOOD PRESSURE_
Everyone has blood pressure. This
pressure helps to circulate blood all
around the body. Your blood
pressure may be different at different
times of the day, depending on how
busy or stressed you are.
You have high blood pressure (also
known as hypertension) when your
blood pressure stays higher than is
needed, even when you are calm and
relaxed.
If high blood pressure is not treated it
can lead to serious health problems.
You may feel fine and have no
symptoms, but eventually it can
cause stroke, heart disease and
kidney failure.
Natrilix helps to lower your blood
pressure.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY NATRILIX HAS
BEEN PRESCRIBED FOR YOU.
BEFORE YOU TAKE
NATRILIX
There are some people who should
not take Natrilix. Please read the lists
below. If you think any of these
situations apply to you, or you have
any questions, please consult your
doctor or pharmacist.
_WHEN YOU MUST NOT TAKE_
_NATRILIX:_
DO NOT TAKE NATRILIX IF:
•
YO

Summary of Product characteristics

NATRILIX
_®_

– DRAFT PRODUCT INFORMATION 

1 (10) 

Version 5 
PRODUCT INFORMATION 

NAME OF THE MEDICINE 

_NATRILIX_
_®_
_ _
Indapamide hemihydrate 2.5mg 

_Chemical structure_:  C
16
H
16
ClN
3
O
3
S, ½ H
2
O 

_ _
_CAS Registry Number_: 26 807-65-8 

DESCRIPTION 

Indapamide  (4-chloro-N(2-methyl-1-indolinyl)-3-sulphamoyl  benzamide  hemihydrate)  is  a  non-
thiazide  indole  derivative  of  chlorosulphonamide.    Indapamide  is  a  white  crystalline  lipophilic 
powder, soluble in methanol, ethanol, acetic acid and ethyl acetate, very slightly soluble in ether, 
chloroform and benzene and practically insoluble in water.   

_Molecular Weight_: 374.85 (Indapamide hemihydrate) 

_Melting point:_ approximately 185°C 

_Excipients _

Maize  starch,  lactose,  povidone,  magnesium  stearate,  talc,  beeswax-white,  titanium  dioxide, 
glycerol, sodium lauryl sulfate, hypromellose, macrogol 6000. 

PHARMACOLOGY 

MECHANISM OF ACTION 

Indapamide  is  an  oral  antihypertensive  agent.    The  mechanism  whereby  indapamide  exerts  its 
antihypertensive action has not been completely elucidated; both vascular and renal actions have 
been implicated. 

At a dose of 2.5mg the renal effects of indapamide are minimal and the antihypertensive effect of 
indapamide has been attributed to a reduction in
vascular reactivity to pressor amines.  The finding 
that indapamide retains its antihypertensive activity to functionally anephric patients lends support 
to the hypothesis. 

The  renal  site  of  action  of  indapamide  is  the  proximal  segment  of  the  distal  tubule.    Indapamide 
appears to have natriuretic properties (sodium and chloride being excreted in equivalent amounts)