NOROMECTIN POUR-ON FOR CATTLE- ivermectin solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

ivermectin (UNII: 8883YP2R6D) (ivermectin - UNII:8883YP2R6D)

Available from:

Norbrook Laboratories Limited

INN (International Name):

ivermectin

Composition:

ivermectin 5 mg in 1 mL

Administration route:

TOPICAL

Prescription type:

OTC

Therapeutic indications:

Noromectin Pour-On (ivermectin topical solution) applied at the recommended dose level of 500 mcg/kg is indicated for the effective control of these parasites. Gastrointestinal Roundworms Lungworms Cattle Grubs Mites Sarcoptes scabiei var. bovis Lice Linognathus vituli Haematopinus eurysternus Damalinia bovis Solenopotes capillatus Horn Flies Haematobia irritans

Product summary:

Noromectin Pour-On (ivermectin topical solution) is available in a 33.8 fl oz/1L bottle with a measure-squeeze-pour-system or in an 84.5 fl oz/2.5 L or 169 oz/5 L collapsible pack, or 676 fl oz/20 L container intended for use with appropriate automatic dosing equipment. Restricted Drug - California. Use Only as Directed. Approved by FDA under ANADA # 200-272 Manufactured by: Norbrook Laboratories Limited Newry, BT35 6PU, Co. Down, Northern Ireland 001670I04 Norbrook ®

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

NOROMECTIN POUR-ON FOR CATTLE - IVERMECTIN SOLUTION
NORBROOK LABORATORIES LIMITED
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NOROMECTIN POUR-ON
(IVERMECTIN TOPICAL SOLUTION)
FOR CATTLE
Contains 5 mg ivermectin/mL
Parasiticide
CONSULT YOUR VETERINARIAN FOR ASSISTANCE IN THE DIAGNOSIS, TREATMENT
AND CONTROL OF PARASITISM.
INTRODUCTION
Noromectin Pour-On (ivermectin topical solution) delivers internal and
external parasite control in one
convenient low-volume application. Noromectin Pour-On (ivermectin
topical solution) contains
ivermectin, a unique chemical entity.
MODE OF ACTION
Ivermectin is a member of the macrocylic lactone class of endectocides
which have a unique mode of
action. Compounds of the class bind selectively and with high affinity
to glutamate-gated chloride ion
channels which occur in invertebrate nerve and muscle cells.
This leads to an increase in the permeability of the cell membrane to
chloride ions with
hyperpolarization of the nerve or muscle cell, resulting in paralysis
and death of the parasite.
Compounds of this class may also interact with other ligand -gated
chloride channels, such as those
gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable to
the fact that mammals do not have
glutamate-gated chloride channels, the macrocylic lactones have a low
affinity for other mammalian
ligand-gated chloride channels and they do not readily cross the
blood-brain barrier.
INDICATIONS
Noromectin Pour-On (ivermectin topical solution) applied at the
recommended dose level of 500
mcg/kg is indicated for the effective control of these parasites.
GASTROINTESTINAL ROUNDWORMS
_Ostertagia ostertagi_
(adults and L4)
(including inhibited stage)
_Haemonchus placei_
(adults and L4)
_Trichostrongylus axei_
(adults and L4)
_T. colubriformis_
(adults and L4)
_Cooperia oncophora_
(adults and L4)
_Cooperia punctata_
(adults and L4)
_Cooperia surnabada_
(adults and L4)
_Strongyloides papillosus_
(adults)
_Oesophagostomum radiatum_
(adults and L4)
_Trichuris spp._
(adults)
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