PROMECTIN B POUR-ON FOR CATTLE- ivermectin cattle pour-on solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

IVERMECTIN (UNII: 8883YP2R6D) (IVERMECTIN - UNII:8883YP2R6D)

Available from:

VEDCO INCORPORATED

INN (International Name):

IVERMECTIN

Composition:

IVERMECTIN 5 mg in 1 mL

Administration route:

TOPICAL

Prescription type:

OTC

Therapeutic indications:

ProMectin® B Pour-On for Cattle applied at the recommended dose level of 500 mcg/kg is indicated for the effective control of these parasites. Gastrointestinal Roundworms Ostertagia ostertagi (including inhibited Stage)             (adults and L4 ) Haemonchus placei                                                       (adults and L4 ) Trichostrongylus axei                                                    (adults and L4 ) T. colubriformis                                                             (adults and L4 ) Cooperia oncophora                                                      (adults and L4 ) Cooperia punctata                                                         (adults and L4 ) Cooperia surnabada                                                      (adults and L4 ) Strongyloides papillosus                                                (adults) Oesophagostomum radiatum                                        (adults and L4 ) Trichuris spp                                                       

Product summary:

ProMectin® B Pour-On for Cattle is available in 250 mL (8.5 fl oz) and 1 L (33.8 fl oz) tip and measure bottles, and 2.5 L (84.5 fl oz), 5 L (169.0 fl oz), and 5 Gallon (639.0 fl oz) containers for use with an appropriate automatic dosing applicator.

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

PROMECTIN B POUR-ON FOR CATTLE- IVERMECTIN CATTLE POUR-ON SOLUTION
VEDCO INCORPORATED
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PROMECTIN
B POUR-ON FOR CATTLE
(IVERMECTIN TOPICAL SOLUTION)
5 MG
IVERMECTIN PER ML
PARASITICIDE
KILLS: ROUNDWORMS (INCLUDING BROWN STOMACH WORM), LUNGWORMS, GRUBS,
SUCKING LICE, BITING LICE, MANGE MITES, HORN FLIES
WARNING! FLAMMABLE! KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME AND
OTHER SOURCES OF IGNITION.
Restricted Drug (California) - Use Only as Directed
APPROVED BY FDA UNDER ANADA # 200-340
FOR ANIMAL USE ONLY • KEEP OUT OF REACH OF CHILDREN
SEE ATTACHED BOOKLET FOR COMPLETE INDICATIONS AND USE DIRECTIONS.
PROMECTIN® B POUR-ON FOR CATTLE
(IVERMECTIN TOPICAL SOLUTION)
APPROVED BY FDA UNDER ANADA # 200-340
CONTAINS 5 MG IVERMECTIN/ML
PARASITICIDE
CONSULT YOUR VETERINARIAN FOR ASSISTANCE IN THE DIAGNOSIS, TREATMENT
AND
CONTROL OF PARASITISM.
INTRODUCTION
ProMectin B Pour-On for Cattle (ivermectin topical solution) delivers
internal and
external parasite control in one convenient low-volume application.
ProMectin B Pour-
On for Cattle contains ivermectin, a unique chemical entity.
MODE OF ACTION
Ivermectin is a member of the macrocylic lactone class of endectocides
which have a
unique mode of action. Compounds of the class bind selectively and
with high affinity to
glutamate-gated chloride ion channels which occur in invertebrate
nerve and muscle
cells.
This leads to an increase in the permeability of the cell membrane to
chloride ions with
hyperpolarization of the nerve or muscle cell, resulting in paralysis
and death of the
®
®
®
hyperpolarization of the nerve or muscle cell, resulting in paralysis
and death of the
parasite. Compounds of this class may also interact with other
ligand-gated chloride
channels, such as those gated by the neurotransmitter
gamma-aminobutyric acid
(GABA).
The margin of safety for compounds of this class is attributable to
the fact that
mammals do not have glutamate-gated chloride channels, the macrocyclic
lactones have
a low affinity for other mammalian ligand-gated chloride channels