PROMECTIN B POUR-ON- ivermectin solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

IVERMECTIN (UNII: 8883YP2R6D) (IVERMECTIN - UNII:8883YP2R6D)

Available from:

Vedco, Inc.

Administration route:

TOPICAL

Prescription type:

OTC

Therapeutic indications:

INDICATIONS ProMectin®  B (ivermectin  topical solution) Pour-On applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites. Gastrointestinal Roundworms Ostertagia ostertagi                       (adults and L4 ) (including inhibited stage) Haemonchus placei                         (adults and L4 ) Trichostrongylus axei                     (adults and L4 ) T. colubriformis                               (adults and L4 ) Cooperia oncophora                         (adults and L4 ) Cooperia punctate                           (adults and L4 ) Cooperia surnabada                         (adults and L4 ) Strongyloides papillosus                  (adults) Oesophagostomum radiatum          (adults and L4 ) Trichuris  spp.                                (adults) Lungworms Dictyocaulus viviparus                   (adults and L4 ) Cattle Grubs                                  (parasitic stages) Hypoderma bovis H. lineatum Mites Sarcoptes scabiei var. bo

Product summary:

HOW SUPPLIED ProMectin®  B (ivermectin topical solution) Pour-On is available in a 5 Liter Pack intended for use with appropriate automatic dosing equipment.

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

PROMECTIN B POUR-ON- IVERMECTIN SOLUTION
VEDCO, INC.
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_PROMECTIN® B_
_POUR-ON FOR CATTLE_
(IVERMECTIN TOPICAL SOLUTION)
APPROVED BY FDA UNDER ANADA # 200-318
CONTAINS 5 MG IVERMECTIN/ML
PARAS ITICIDE
CONSULT YOUR VETERINARIAN FOR ASSISTANCE IN THE DIAGNOSIS, TREATMENT
AND CONTROL OF
PARAS ITIS M.
INTRODUCTION
ProMectin® B (ivermectin topical solution) Pour-On delivers internal
and external parasite control in
one convenient low-volume application. ProMectin® B (ivermectin
topical solution) Pour-On contains
ivermectin, a unique chemical entity.
MODE OF ACTION
Ivermectin is a member of the macrocyclic lactone class of
endectocides which have a unique mode of
action. Compounds of the class bind selectively and with high affinity
to glutamate-gated chloride ion
channels which occur in invertebrate nerve and muscle cells. This
leads to an increase in the
permeability of the cell membrane to chloride ions with
hyperpolarization of the nerve or muscle cell,
resulting in paralysis and death of the parasite. Compounds of this
class may also interact with other
ligand-gated chloride channels, such as those gated by the
neurotransmitter gamma-aminobutyric acid
(GABA). The margin of safety for compounds of this class is
attributable to the fact that mammals do
not have glutamate-gated chloride channels, the macrocyclic lactones
have a low affinity for other
mammalian ligand-gated chloride channels and they do not readily cross
the blood-brain barrier.
INDICATIONS
ProMectin® B (ivermectin topical solution) Pour-On applied at the
recommended dose level of 500
mcg/kg is indicated for the effective treatment and control of these
parasites.
GASTROINTESTINAL ROUNDWORMS
_Ostertagia ostertagi _(adults and L )
(including inhibited stage)
_Haemonchus placei _(adults and L )
_Trichostrongylus axei _(adults and L )
_T. colubriformis _(adults and L )
_Cooperia oncophora _(adults and L )
_Cooperia punctate _(adults and L )
_Cooperia surnabada _(adults and L )
_Strongyloides papillosus _(adults)
_Oesophagostomum radiatum _(ad