Qilu Pharmaceutical (Inner Mongolia) 10% ww Bacitracin Zinc Premix

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

BACITRACIN ZINC

Available from:

Gladron Chemicals Sdn Bhd

INN (International Name):

BACITRACIN ZINC

Units in package:

25 kg

Manufactured by:

Qilu Pharmaceutical (Inner Mongolia) Co., Ltd.

Summary of Product characteristics

PACKAGE INSERT
QILU PHARMACEUTICAL (INNER MONGOLIA) 10% W / W
BACITRACIN ZINC PREMIX
Brand of Product Name
Qilu Pharmaceutical (Inner Mongolia) 10% w/w Bacitracin
Zinc Premix
Strength of Active Substance(s)
Each kilogram product contains 100 g bacitracin zinc
Product Description
Slightly brown or tawny granule
Pharmacodynamics
：
Bacitracin is produced by Bacillus licheniformis and Bacillus
subtilis,
and
is
a
mixture
of
several
closely
related
polypeptides, mainly consisting of bacitracin A, B1, B2, C
and a small portion of bacitracin F (with relative ratio's of
approximately 53%, 22%, 13%, 8%, and 4%, respectively,
although this may vary according to producing species and/or
production
conditions).
The
zinc
salt
adds
stability
particularly during storage of the product.
Bacitracin
is
mainly
active
against
Gram-positive
microorganisms. The activities of each of bacitracins B1, B2,
and C constitute about 90% of the antibacterial activity of
bacitracin A. Bacitracin F is almost inactive.
Pharmacokinetics
：
After oral application to rats, chickens and pigs, bacitracin is
hardly
absorbed
from
the
gastrointestinal
tract,
and
the
distribution
to
organs
and
tissues
is
negligible.
In
rats,
chickens and pigs, approximately 95% of an oral dose is
excreted via faeces, and only 3% or less vis urine. Bacitracin
is metabolized to amino acids and smaller peptides via the
main
metabolite
desamidobacitracin,
which
is
microbiologically inactive. Main metabolites in faeces are
bacitracin A, B1, B2, F, desamidobacitracin and catabolic
peptides. In urine and bile only hydrolytic cleavage products
(di- and tripeptides) are present.
Indication
For
the
treatment
of
Necrotic
Enteritis
(Clostridium
Perfringens Types A and C) and as an aid in the prevention
of Necrotic Enteritis in poultry.
Dosage
Treatment of Necrotic Enteritis: Add 2kg of Bacitracin Zinc
Premix 10% w/w Granule per tonne of feed to produce a
concentration of 200g of bacitracin per tonne of finished feed.
Feed for 5-7 days.
Aid in the Prevention of Necrotic Enteritis: A