Qilu Pharmaceutical (Inner Mongolia) 15% ww Bacitracin Zinc Premix

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

BACITRACIN ZINC

Available from:

Gladron Chemicals Sdn Bhd

INN (International Name):

BACITRACIN ZINC

Units in package:

25 kg

Manufactured by:

Qilu Pharmaceutical (Inner Mongolia) Co., Ltd.

Summary of Product characteristics

PACKAGE INSERT
QILU PHARMACEUTICAL (INNER MONGOLIA)
15% W/W
BACITRACIN ZINC PREMIX
Brand of Product Name
Qilu Pharmaceutical (Inner Mongolia) 15% w/w Bacitracin Zinc
Premix
Strength of Active Substance(s)
Each kilogram product contains 150 g bacitracin zinc
Product Description
Slightly brown or tawny granule
Pharmacodynamics
：
Bacitracin is produced by _ Bacillus licheniformis_ and _ Bacillus _
_subtilis_, and is a mixture of several closely related polypeptides,
mainly consisting of bacitracin A, B1, B2, C and a small portion
of bacitracin F (with relative ratio's of approximately 53%, 22%,
13%,
8%,
and
4%,
respectively,
although
this
may
vary
according to producing species and/or production conditions).
The zinc salt adds stability particularly during storage of the
product.
Bacitracin
is
mainly
active
against
Gram-positive
microorganisms. The activities of each of bacitracins B1, B2,
and C constitute about 90% of the antibacterial activity of
bacitracin A. Bacitracin F is almost inactive.
Pharmacokinetics
：
After oral application to rats, chickens and pigs, bacitracin is
hardly
absorbed
from
the
gastrointestinal
tract,
and
the
distribution to organs and tissues is negligible. In rats, chickens
and pigs, approximately 95% of an oral dose is excreted via
faeces, and only 3% or less vis urine. Bacitracin is metabolized
to amino acids and smaller peptides via the main metabolite
desamidobacitracin, which is microbiologically inactive. Main
metabolites
in
faeces
are
bacitracin
A,
B1,
B2,
F,
desamidobacitracin and catabolic peptides. In urine and bile
only hydrolytic cleavage products (di- and tripeptides) are
present.
Indication
For the treatment of Necrotic Enteritis (Clostridium Perfringens
Types A and C) and as an aid in the prevention of Necrotic
Enteritis in poultry.
Dosage
Treatment of Necrotic Enteritis: Add 1.33kg of Bacitracin Zinc
Premix 15% w/w Granule per tonne of feed to produce a
concentration of 200g of bacitracin per tonne of finished feed.
Feed for 5-7 days.
Aid in the Prevention of Necrotic En