Country: South Africa
Language: English
Source: South African Health Products Regulatory Authority (SAHPRA)
Ranbaxy
RANFEN 200 Tablets RANFEN 400 Tablets SCHEDULING STATUS: S3 PROPRIETARY NAME (and dosage form): RANFEN 200 Tablets RANFEN 400 Tablets COMPOSITION: Ranfen 200 Tablets Each film coated tablet contains ibuprofen 200 mg Ranfen 400 Tablets Each film coated tablet contains ibuprofen 400 mg PHARMACOLOGICAL CLASSIFICATION: A 3.1 Antirheumatics (anti-inflammatory agents) PHARMACOLOGICAL ACTION: Mechanism of Action Ibuprofen acts by inhibiting the activity of enzyme cyclo-oxygenase, resulting in decreased formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Pharmacokinetics and Metabolism Ibuprofen is rapidly absorbed after oral administration and peak concentrations in plasma are observed after 1 to 2 hours. The half- life in plasma is about 2 hours. Ibuprofen is extensively (99%) bound to plasma proteins. Ibuprofen passes slowly into synovial spaces and may remain there in higher concentration as the concentrations in plasma decline. The excretion of ibuprofen is rapid and complete. More than 90% of an ingested dose is excreted in the urine as metabolites or their conjugates, and no ibuprofen per se is found in the urine. The major metabolites are a hydroxylated and a carboxylated compound. INDICATIONS: Ibuprofen is indicated: For the treatment of rheumatic diseases such as: * Rheumatoid arthritis * Osteoarthritis * Ankylosing spondylitis * Juvenile rheumatoid arthritis For the relief of mild to moderate pain especially when anti- inflammatory actions may also be desired e.g., following dental or obstetric surgery, and for relief of musculoskeletal pain due to soft tissue athletic injuries (strains or sprains). For the relief of pain and inflammation of acute gouty arthritis. In the treatment of painful nonrheumatic inflammatory conditions such as athletic injuries, Read the complete document