Country: United States
Language: English
Source: NLM (National Library of Medicine)
SINCALIDE (UNII: M03GIQ7Z6P) (SINCALIDE - UNII:M03GIQ7Z6P)
AnazaoHealth Corporation
SINCALIDE
SINCALIDE 3 ug
INTRAVENOUS
PRESCRIPTION DRUG
Sincalide may be used: to stimulate gallbladder contraction, as may be assessed by various methods of diagnostic imaging, or to obtain by duodenal aspiration a sample of concentrated bile for analysis of cholesterol, bile salts, phospholipids, and crystals; to stimulate pancreatic secretion (especially in conjunction with secretin) prior to obtaining a duodenal aspirate for analysis of enzyme activity, composition, and cytology; to accelerate the transit of a barium meal through the small bowel, thereby decreasing the time and extent of radiation associated with fluoroscopy and x-ray examination of the intestinal tract Gallbladder stones (stimulation of gallbladder contraction in patients with small gallbladder stones may lead to the evacuation of the stones from the gallbladder resulting in their lodging in the cystic duct or in the common bile duct; however, this is unlikely with usual doses of Sincalide since complete contraction of the gallbladder is not induced.)
unapproved drug other
SINCALIDE - SINCALIDE INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION ANAZAOHEALTH CORPORATION _Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been_ _approved by FDA. For further information about unapproved drugs, click here._ ---------- SINCALIDE Dear Medical Professional, Per your order, we have compounded Sincalide as a sterile lyophilized powder, sealed under nitrogen. The characteristics of this compounded preparation are as follows DESCRIPTION Upon reconstitution with 3 ml normal saline, the vial contains 1 mcg/ml Sincalide 5 mg Mannitol Lyophilized product should be stored at room temperature. After reconstitution with normal saline, the vial can be stored in the refrigerator for use within 12 hours. Normal dosing is 0.02 micrograms per kilogram patient weight. A 70 kg patient would receive 1.4 mcg or 1.4 ml CLINICAL PHARMACOLOGY Sincalide, a synthetically prepared C-terminal octapeptide of the natural hormone cholecystokinin, induces contraction of the gallbladder muscle, resulting in reduction of gallbladder size and evacuation of bile. Also, Sincalide, like cholecystokinin, stimulates secretion of pancreatic enzymes;Sincalide decreases intestinal transit time; delays gastric emptying; decreases esophageal sphincter tone; inhibits gastric secretions; and stimulates intestinal muscle. Maximum contraction (40% reduction in size) of gallbladder occurs 5 to 15 minutes after injection. Gallbladder returns to basal size within 1 hour INDICATIONS AND USAGE Sincalide may be used: to stimulate gallbladder contraction, as may be assessed by various methods of diagnostic imaging, or to obtain by duodenal aspiration a sample of concentrated bile for analysis of cholesterol, bile salts, phospholipids, and crystals; to stimulate pancreatic secretion (especially in conjunction with secretin) prior to obtaining a duodenal aspirate for analysis of enzyme activity, composition, and cytology; to accelerate the transit of a barium meal through the small bowel, thereby decre Read the complete document