Terry White Chemists Gliclazide MR

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Gliclazide

Available from:

Apotex Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

TERRY WHITE CHEMISTS
GLICLAZIDE MR

_30 MG TABLETS_
_Modified Release tablets containing the active ingredient gliclazide_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about gliclazide. It does not
contain all the available information.
It does not take the place of talking to
your doctor, pharmacist or diabetes
educator.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
this medicine may be available.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is Terry
White Chemists Gliclazide MR. It
contains the active ingredient
gliclazide.
The tablets release the gliclazide
gradually over 24 hours.
The medicine is used to control,
blood glucose in patients with Type
II diabetes mellitus.
This type of diabetes is also known
as non-insulin-dependent diabetes
mellitus (NIDDM) or maturity onset
diabetes.
Gliclazide is used when diet and
exercise are not enough to control
your blood glucose.
Gliclazide can be used alone, or
together with other medicines for
treating diabetes
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor may have prescribed this
medicine for another reason.
This medicine is available only with
a doctor's prescription.
_HOW IT WORKS_
Gliclazide belongs to a group of
medicines called the sulfonylureas.
Gliclazide lowers high blood glucose
by increasing the amount of

Summary of Product characteristics

Product Information – Australia 
Terry White Chemists Gliclazide MR Tablets  

Page 1/9 
TERRY WHITE CHEMISTS GLICLAZIDE MR 30 MG TABLETS 

NAME OF THE MEDICINE 
Gliclazide 

CHEMICAL NAME : 
 1-(3-azabicyclo[3.3.0]oct-3-yl)-3-_p_-tolylsulphonylurea. 

CHEMICAL STRUCTURE : 

MOLECULAR FORMULA :  

C
15
H
21
N
3
O
3
S 

MOLECULAR WEIGHT :  

323.4 

CAS REGISTRY NUMBER :  
21187-98-4 

DESCRIPTION 

Gliclazide is a white or almost white powder which is practically insoluble in water. Freely soluble in 
dichloromethane, sparingly soluble in acetone and slightly soluble in ethanol 96%. The melting point 
of gliclazide is approximately 168°C. 

Gliclazide MR 30 mg tablets are intended
for oral administration. Each tablet contains gliclazide 30 mg. 

They are white to off-white, flat faced, beveled edge, capsule
shaped tablets, engraved “APO 30” on one 
side and plain on the other side. 

In addition to gliclazide, each tablet contains the following
inactive ingredients: hypromellose, stearic acid 
and silica, colloidal anhydrous. 

PHARMACOLOGY 
Gliclazide is an oral hypoglycaemic sulfonylurea which differs from other related
compounds. 
It has an N-containing
heterocyclic ring with an endocyclic bond. 
Gliclazide reduces blood glucose levels by stimulating insulin
secretion from the beta-cells of the 
Islets of Langerhans. Gliclazide shows high affinity, strong selectivity and 
reversible binding to the β-
cell KATP channels with
a low affinity for cardiac and vascular KATP channels. 
Increased postprandial insulin and C-peptide
secretion persists after two years of treatment. 
Gliclazide also has extra-pancreatic effects and
haemovascular properties. 

Effects on insulin release 
In type II diabetes, gliclazide restores the
first peak of insulin secretion in respons