VETRIMEC PLUS- ivermectin and clorsulon injection

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

IVERMECTIN (UNII: 8883YP2R6D) (IVERMECTIN - UNII:8883YP2R6D), CLORSULON (UNII: EG1ZDO6LRD) (CLORSULON - UNII:EG1ZDO6LRD)

Available from:

VetOne

Administration route:

SUBCUTANEOUS

Prescription type:

OTC

Therapeutic indications:

INDICATIONS: Vetrimec™ Plus is indicated for the effective treatment and control of the following parasites in cattle: Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi (including inhibited O. ostertagi ) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis Cooperia oncophora C. punctata C. pectinata Bunostomum phlebotomum Nematodirus helvetianus (adults only) N. spathiger (adults only) Oesophagostomum radiatum Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus Liver Flukes: Fasciola hepatica (adults only) Cattle Grubs (parasitic stages): Hypoderma bovis H. lineatum Sucking Lice: Linognathus vituli Haematopinus eurysternus Solenopotes capillatus Mange Mites (Cattle Scab*): Psoroptes ovis (syn. P. communis var. bovis ) Sarcoptes scabiei var. bovis Persistent Activity: Ivermectin and clorsulon injection has been proved to effectively control infections and to protect cattle from reinfection with Dictyocaulus viviparus and

Product summary:

HOW SUPPLIED: Vetrimec™ Plus is available in two ready-to-use sizes: The 500 mL plastic bottle is suitable for use with automatic syringe equipment. Each bottle contains suffcient solution to treat 100 head of 550 lb (250 kg) cattle. The 1000 mL plastic bottle is suitable for use with automatic syringe equipment. Each bottle contains suffcient solution to treat 200 head of 550 lb (250 kg) cattle.

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

VETRIMEC PLUS- IVERMECTIN AND CLORSULON INJECTION
VETONE
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APPROVED BY FDA UNDER ANADA # 200-450
RESTRICTED DRUG (CALIFORNIA)-USE ONLY AS DIRECTED
VETRIMEC™ PLUS
(IVERMECTIN AND CLORSULON)
INJECTION FOR CATTLE
FOR THE EFFECTIVE TREATMENT AND CONTROL OF INTERNAL PARASITES,
INCLUDING ADULT LIVER FLUKES, AND
EXTERNAL PARASITES.
CONSULT YOUR VETERINARIAN FOR ASSISTANCE IN THE DIAGNOSIS, TREATMENT
AND CONTROL OF PARASITISM.
INTRODUCTION: The ability of ivermectin to deliver internal and
external parasite control has been
proven in cattle markets around the world. Now, Vetrimec™ Plus
combines ivermectin, the active
ingredient of Vetrimec™ 1%, with clorsulon, an effective adult
flukicide. A single injection of
Vetrimec™ Plus (ivermectin and clorsulon) offers all the benefts of
Vetrimec™ 1% plus control of
adult_ Fasciola hepatica_.
THE DOSAGE LEVEL OF CLORSULON SUPPLIED BY VETRIMEC™ PLUS IS
EFFECTIVE ONLY AGAINST ADULT LIVER
FLUKES (_FASCIOLA HEPATICA_).
PRODUCT DESCRIPTION: Vetrimec™ Plus is a ready-to-use sterile
solution containing 1% w/v
ivermectin, 10% w/v clorsulon, 40% glycerol formal, and propylene
glycol, q.s. ad 100%. It is
formulated to deliver the recommended dose level of 200 mcg
ivermectin/kg and 2 mg clorsulon/kg
given subcutaneously behind the shoulder at the rate of 1 mL per 110
lb (50 kg) body weight.
MODE OF ACTION: Ivermectin is a member of the macrocyclic lactone
class of endectocides which
have a unique mode of action. Compounds of the class bind selectively
and with high affnity to
glutamate-gated chloride ion channels which occur in invertebrate
nerve and muscle cells. This leads to
an increase in the permeability of the cell membrane to chloride ions
with hyperpolarization of the
nerve or
muscle cell, resulting in paralysis and death of the parasite.
Compounds of this class may also interact
with other ligand-gated chloride channels, such as those gated by the
neurotransmitter gamma-
aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable