Zindaclin

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Clindamycin phosphate

Available from:

Actavis Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

ZINDACLIN
®   
1%W/W CLINDAMYCIN (_AS CLINDAMYCIN PHOPSHATE_) 

CONSUMER MEDICINE INFORMATION 

WHAT IS IN THIS LEAFLET?   

Important information you 
should read before you use 
Zindaclin. 

Please read this leaflet carefully 
before you use Zindaclin. It 
contains a summary of the 
information about your 
medicine. If you have any 
questions about Zindaclin, 
please ask your doctor or 
pharmacist. 

Keep the leaflet with the 
medicine – you may need to 
read it again. 

REMEMBER 
This medicine is only for you. 
Only a doctor can prescribe it 
for you. Never give it to other 
people. It may harm them, even 
though their symptoms may 
seem to be the same as yours. 

WHAT IS ZINDACLIN USED FOR? 

Zindaclin is used to treat acne 
(spots). 

Zindaclin contains clindamycin 
phosphate which breaks down 
in the skin to clindamycin which 
is an antibiotic. Zindaclin 
reduces the number of bacteria. 
This will help to stop the pores 
becoming blocked and new 
spots forming. Zindaclin may 
also help to reduce the redness 
of the spots you already have. 

As with other products it will 
take some time before you see 
your acne improving. 

Acne is an extremely common 
skin condition. During 
adolescence grease glands in 
the skin produce extra grease in 
response to normal amounts of 
sex hormones in your body and 
this can cause blocked pores 
(i.e. blackheads). When this 
happens the pores are invaded 
by bacteria. 
This produces chemicals which 
go into deeper parts of the skin 
to produce red spots filled with  
pus. In some people acne starts 
or continues after adolescence. 

BEFORE YOU USE ZINDACLIN 

_Is there any reason for not _
_being given Zindaclin? _
_ _
Make sure it is safe for you to 
use Zindaclin. 

_If you answer ‘YES’ to any of _
_the following questions, or you _
_are not sure, please tell your _
_doctor or pharmacist. _

• 

Summary of Product characteristics

110919 Zindaclin PI v2 

Page 1 of 7 

ZINDACLIN: PRODUCT INFORMATION   

NAME OF THE DRUG: _ _
Clindamycin phosphate 
Clindamycin phosphate is a water soluble ester of the
semi-synthetic antibiotic produced by a 7(S)-
chloro-substitution of the 7(R)hydroxyl group and phosphorylation of
the C(2)-OH group of the 
parent antibiotic lincomycin. It is a white to off-white, odourless,
hygroscopic, crystalline powder, 
found to be soluble in water, slightly soluble in dehydrated alcohol,
sparingly soluble in acetone, 
and practically insoluble in chloroform and ether.  
The chemical name for clindamycin phosphate is methyl
7-chloro-6,7,8-trideoxy -6-(1-methyl-
_trans_-4-propyl-
L
-2-pyrrolidinecarboxamido)-1-thio-
L
-_threo_-(-D-_galacto_-octopyranoside-2-_O_-
dihydrogen phosphate). It has a molecular weight of 504.96, and the
molecular formula is 
C
18
H
34
ClN
2
0
8
PS 
OH
OH
O
SCH 3
HO
O
OH
H
O
H
H
H
H
H
H
C 3H 7
CH 3
N
C
NH
CH 3
C
C
H
H
Cl
H
H
O
H
P
H

CAS Number: 24729-96-2 

DESCRIPTION:- 
White, translucent gel. 1g of gel contains 11.88mg clindamycin
phosphate equivalent to 10.00mg 
clindamycin (1% w/w). 
Excipients: Propylene glycol, Purified water, Ethanol 96%, Zinc
acetate dihydrate, 
Hydroxyethylcellulose, Sodium hydroxide 30% (w/w) 
PHARMACOLOGY:- 
_PHARMACODYNAMICS  _
Pharmacotherapeutic group: Antiinfectives for treatment of acne  ATC
code: D10A F01 
ZINDACLIN contains clindamycin phosphate which is hydrolysed in the
skin to the active 
constituent clindamycin.  Clindamycin is a lincosamide antibiotic
with primarily bacteriostatic 
110919 Zindaclin PI v2 

Page 2 of 7 

action against Gram positive aerobes and wide range of anaerobic
bacteria
.  
_In vitro_, Clindamycin 
MIC was 0.4 µg/mL against _P.acnes_. Cross resistance has
been shown between clindamycin and 
erythromycin. 
When clindamycin phosphate is applied cutaneously, clindamycin is
found in comedone samples at 
sufficient levels to be active aga