País: Estados Unidos
Idioma: inglés
Fuente: NLM (National Library of Medicine)
pentobarbital sodium (UNII: NJJ0475N0S) (pentobarbital - UNII:I4744080IR), phenytoin sodium (UNII: 4182431BJH) (phenytoin - UNII:6158TKW0C5)
Merck Sharp & Dohme Corp.
INTRACARDIAC
PRESCRIPTION
FOR DOGS ONLY NADA #119-807 PRODUCT INFORMATION CAUTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. INDICATIONS For use in dogs for humane, painless, and rapid euthanasia.
HOW SUPPLIED BEUTHANASIA-D SPECIAL EUTHANASIA SOLUTION is available in 100-mL multiple-dose vials, NDC 0061-0473-05. Manufactured by a nonsterilizing process. STORAGE Store between 15° and 30°C (59° and 86°F).
New Animal Drug Application
BEUTHANASIA-D SPECIAL- PENTOBARBITAL SODIUM AND PHENYTOIN SODIUM INJECTION, SOLUTION MERCK SHARP & DOHME CORP. ---------- BEUTHANASIA -D SPECIAL (EUTHANASIA SOLUTION) CIII FOR DOGS ONLY NADA #119-807 PRODUCT INFORMATION CAUTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION A nonsterile solution containing pentobarbital sodium and phenytoin sodium as the active ingredients. Rhodamine B, a bluish-red fluorescent dye, is included in the formulation to help distinguish it from parenteral drugs intended for therapeutic use. Although the solution is not sterile, benzyl alcohol, a bacteriostat, is included to retard the growth of microorganisms. EACH ML CONTAINS: _active ingredients:_ 390 mg pentobarbital sodium (barbituric acid derivative), 50 mg phenytoin sodium; _inactive ingredients:_ 10% ethyl alcohol, 18% propylene glycol, 0.003688 mg rhodamine B, 2% benzyl alcohol (preservative), purified water qs. Sodium hydroxide and/or hydrochloric acid may be added to adjust pH. ACTIONS BEUTHANASIA-D SPECIAL EUTHANASIA SOLUTION contains two active ingredients which are chemically compatible but pharmacologically different. Each ingredient acts in such a manner so as to cause humane, painless, and rapid euthanasia. Euthanasia is due to cerebral death in conjunction with respiratory arrest and circulatory collapse. Cerebral death occurs prior to cessation of cardiac activity. When administered intravenously, pentobarbital sodium produces rapid anesthetic action. There is a smooth and rapid onset of unconsciousness. At the lethal dose, there is depression of vital medullary respiratory and vasomotor centers. When administered intravenously, phenytoin sodium produces toxic signs of cardiovascular collapse and/or central nervous system depression. Hypotension occurs when the drug is administered rapidly. PHARMACODYNAMIC ACTIVITY: The sequence of events leading to humane, painless, and rapid euthanasia following intravenous injection of BEUTHANASIA-D SPECIAL EUTHANASIA SOLUTION is Leer el documento completo