País: Malasia
Idioma: inglés
Fuente: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
AMLODIPINE BESILATE
HOVID BERHAD
AMLODIPINE BESILATE
30Tablet Tablets; 100 Tablet Tablets
HOVID BERHAD
NOT APPLICABLE Leer el documento completo
DESCRIPTION HOVASC 5MG TABLET Oblong, white to off white uncoated tablet; bevel edged, shallow convex with break bar on one face and “HOVID” embossed on another face. HOVASC 10MG TABLET Oblong, white to off white uncoated tablet; bevel edged, shallow convex with break bar on one face and “HOVID” embossed on the other face. COMPOSITION Each uncoated tablet contains: HOVASC 5MG TABLET Amlodipine Besilate equivalent to Amlodipine 5mg HOVASC 10MG TABLET Amlodipine Besilate equivalent to Amlodipine 10mg ACTIONS AND PHARMACOLOGY Amlodipine is a dihydropyridine calcium antagonist. It acts by selective inhibition of transmembrane influx of calcium ions into the cardiac muscle and vascular smooth muscle through specific ion channels; thus modulating the contractile process of these cells. Amlodipine has a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Amlodipine exhibits negative inotropic effects _ in vivo_, but appears to have no significant effect on the sinoatrial or atrioventricular node in humans. Although not fully defined, the mechanism of action of amlodipine in relieving angina is thought to be as follows: EXERTIONAL ANGINA Amlodipine reduces the total peripheral resistance (afterload) against which the heart works and reduces the rate pressure product. Therefore, in patients with exertional angina, myocardial oxygen demand is reduced, at any given level of exercise. VASOSPASTIC ANGINA Amlodipine has been demonstrated to block constriction and restore blood flow in coronary arteries and arterioles in response to calcium, potassium epinephrine, serotonin, and thromboxane A 2 analog in experimental animal models and in human coronary vessels _in _ _vitro_. This inhibition of coronary spasm is responsible for the effectiveness of amlodipine in vasospastic (Prinzmetal's or variant) angina. PHARMACOKIN Leer el documento completo