País: Estados Unidos
Idioma: inglés
Fuente: NLM (National Library of Medicine)
Pentobarbital Sodium (UNII: NJJ0475N0S) (Pentobarbital - UNII:I4744080IR), Phenytoin Sodium (UNII: 4182431BJH) (Phenytoin - UNII:6158TKW0C5)
VETONE
INTRACARDIAC
PRESCRIPTION
For use in dogs for humane, painless, and rapid euthanasia.
Pentobarbital Sodium and Phenytoin Sodium is available in 100 mL multi-dose vials in package of one, NDC 13985-992-90. Manufactured by a nonsterilizing process. Store at controlled room temperature 20° to 25°C (68° to 77°F). Use contents within 60 days of first puncture. Approved by FDA under ANADA # 200-614 VET one® Distributed by: MWI Boise, ID 83705 www.VetOne.net MVPP00N Rev. 11/20
Abbreviated New Animal Drug Application
PENTOBARBITAL SODIUM AND PHENYTOIN SODIUM- PENTOBARBITAL SODIUM AND PHENYTOIN SODIUM INJECTION, SOLUTION VETONE ---------- PENTOBARBITAL SODIUM AND PHENYTOIN SODIUM CIII EUTHANASIA SOLUTION FOR DOGS ONLY CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: A nonsterile solution containing pentobarbital sodium and phenytoin sodium as the active ingredients. Rhodamine B, a bluish-red fluorescent dye, is included in the formulation to help distinguish it from parenteral drugs intended for therapeutic use. Although the solution is not sterile, benzyl alcohol, a bacteriostat, is included to retard the growth of microorganisms. EACH ML CONTAINS: _active ingredients:_ 390 mg pentobarbital sodium (barbituric acid derivative), 50 mg phenytoin sodium; _inactive ingredients:_ 10% ethyl alcohol, 18% propylene glycol, 0.003688 mg rhodamine B, 2% benzyl alcohol (preservative), purified water qs. Sodium hydroxide and/or hydrochloric acid may be added to adjust pH. ACTIONS: Pentobarbital Sodium and Phenytoin Sodium euthanasia solution contains two active ingredients which are chemically compatible but pharmacologically different. Each ingredient acts in such a manner so as to cause humane, painless, and rapid euthanasia. Euthanasia is due to cerebral death in conjunction with respiratory arrest and circulatory collapse. Cerebral death occurs prior to cessation of cardiac activity. When administered intravenously, pentobarbital sodium produces rapid anesthetic action. There is a smooth and rapid onset of unconsciousness. At the lethal dose, there is depression of vital medullary respiratory and vasomotor centers. When administered intravenously, phenytoin sodium produces toxic signs of cardiovascular collapse and/or central nervous system depression. Hypotension occurs when the drug is administered rapidly. PHARMACODYNAMIC ACTIVITY: The sequence of events leading to humane, painless, and rapid euthanasia following intravenous injection of Pentobarbital Sodium and Phenytoin So Leer el documento completo