PENTOBARBITAL SODIUM AND PHENYTOIN SODIUM injection, solution

País: Estados Unidos

Idioma: inglés

Fuente: NLM (National Library of Medicine)

Ingredientes activos:

Pentobarbital Sodium (UNII: NJJ0475N0S) (Pentobarbital - UNII:I4744080IR), Phenytoin Sodium (UNII: 4182431BJH) (Phenytoin - UNII:6158TKW0C5)

Disponible desde:

Vetone

Vía de administración:

INTRACARDIAC

tipo de receta:

PRESCRIPTION

indicaciones terapéuticas:

For use in dogs for humane, painless, and rapid euthanasia.

Resumen del producto:

Pentobarbital Sodium and Phenytoin Sodium is available in 100 mL multi-dose vials in package of one, NDC 86136-007-90. Manufactured by a nonsterilizing process. Store at controlled room temperature 20° to 25°C (68° to 77°F). Use contents within 60 days of first puncture. Approved by FDA under ANADA # 200-614 Distributed by: MWI Boise, ID 83705 www.VetOne.net MVPP00N Rev. 07/21

Estado de Autorización:

Abbreviated New Animal Drug Application

Ficha técnica

PENTOBARBITAL SODIUM AND PHENYTOIN SODIUM- PENTOBARBITAL SODIUM
AND PHENYTOIN SODIUM INJECTION, SOLUTION
VETONE
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PENTOBARBITAL SODIUM AND PHENYTOIN SODIUM
CIII
EUTHANASIA SOLUTION
FOR DOGS ONLY
CAUTION: Federal law restricts this drug to use by or on the order of
a licensed
veterinarian.
DESCRIPTION:
A nonsterile solution containing pentobarbital sodium and phenytoin
sodium as the
active ingredients. Rhodamine B, a bluish-red fluorescent dye, is
included in the
formulation to help distinguish it from parenteral drugs intended for
therapeutic use.
Although the solution is not sterile, benzyl alcohol, a bacteriostat,
is included to retard
the growth of microorganisms.
EACH ML CONTAINS: _active ingredients:_ 390 mg pentobarbital sodium
(barbituric acid
derivative), 50 mg phenytoin sodium; _inactive ingredients:_ 10% ethyl
alcohol, 18%
propylene glycol, 0.003688 mg rhodamine B, 2% benzyl alcohol
(preservative), purified
water qs. Sodium hydroxide and/or hydrochloric acid may be added to
adjust pH.
ACTIONS:
Pentobarbital Sodium and Phenytoin Sodium euthanasia solution contains
two active
ingredients which are chemically compatible but pharmacologically
different. Each
ingredient acts in such a manner so as to cause humane, painless, and
rapid euthanasia.
Euthanasia is due to cerebral death in conjunction with respiratory
arrest and circulatory
collapse. Cerebral death occurs prior to cessation of cardiac
activity.
When administered intravenously, pentobarbital sodium produces rapid
anesthetic
action. There is a smooth and rapid onset of unconsciousness. At the
lethal dose, there
is depression of vital medullary respiratory and vasomotor centers.
When administered intravenously, phenytoin sodium produces toxic signs
of
cardiovascular collapse and/or central nervous system depression.
Hypotension occurs
when the drug is administered rapidly.
PHARMACODYNAMIC ACTIVITY: The sequence of events leading to humane,
painless, and
rapid euthanasia following intravenous injection of Pentobarbital
Sodium and Phenytoin
So