PRAZIVET PLUS (PRAZIQUANTEL PYRANTEL PAMOATE & FEBANTEL TABLETS)

País: Malasia

Idioma: inglés

Fuente: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredientes activos:

PRAZIQUANTEL; PYRANTEL PAMOATE; FEBANTEL

Disponible desde:

KM Vet Pharm Sdn Bhd

Designación común internacional (DCI):

PRAZIQUANTEL; PYRANTEL PAMOATE; FEBANTEL

Unidades en paquete:

2 x 10 Tablets

Fabricado por:

M/s. Smith & Kenner Pharmaceuticals Pvt. Ltd

Ficha técnica

For the use only of a Veterinary Medical Practitioner or a Hospital or
a Laboratory or a farm
Praziquantel, Pyrantel Pamoate & Febantel Tablets
PRAZIVET PLUS
COMPOSITION:
EACH UNCOATED TABLET CONTAINS
Praziquantel USP
50mg
Pyrantel Pomoate USP 144mg
Febantel
150mg
PRODUCT DESCRIPTION
Pale Yellow Coloured Uncoated Tablets
PHARMACODYNAMICS
This product contains anthelmintics active against gastrointestinal
roundworms and tapeworms.
The product contains three active substances:
1.
Febantel, a probenzimidazole,
2.
Pyrantel embonate (pamoate) a tetrahydropyrimidine derivative,
3.
Praziquantel, a partially hydrogenated pyrazinoisoquinoline derivative
_ATC VetCode_: QP52AF30
In this fixed combination pyrantel and febantel act against all
relevant nematodes (ascarids,
hookworms, and whipworms) in dogs. In particular the activity spectrum
covers Toxocara canis,
Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum and
Trichuris vulpis. This
combination shows synergistic activity in the case of hookworms and
febantel is effective against T.
vulpis.
The spectrum of activity of praziquantel covers all important cestode
species in dogs, in particular
Taenia spp; Dipylidium caninum; Echinococcus granulosus and
Echinococcus multilocularis.
Praziquantel acts against all adult and immature forms of these
parasites.
Praziquantel is very rapidly absorbed through the parasite’s surface
and distributed throughout the
parasite. Both in vitro and in vivo studies have shown that
praziquantel causes severe damage to
the parasite integument, resulting in the contraction and paralysis of
the parasites. There is an
almost instantaneous tetanic contraction of the parasite musculature
and a rapid vacuolisation of
the syncytial tegument. This rapid contraction has been explained by
changes in divalent cation
fluxes, especially calcium.
Pyrantel acts as a cholinergic agonist. Its mode of action is to
stimulate nicotinic cholinergic
receptors of the parasite, induce spastic paralysis of the nematodes
and thereby allow removal from
th