מדינה: אינדונזיה
שפה: אינדונזית
מקור: Badan Pengawas Obat dan Makanan RI - Indonesian Food and Drug Supervisory Agency
CIPROFLOXACIN LACTATE
BAYER INDONESIA - Indonesia
CIPROFLOXACIN LACTATE
254.4 MG
INFUS
DUS, 1 BOTOL @ 100 ML
BAYER AG - Federal Republic of Germany
2020-04-04
Ciproxin ® 400mg/200mL/Ciprofloxacin/Infus/New Site Fresenius Kabi - BEC 14462&13271 1 CIPROXIN ® INFUSION SOLUTION Important information, please read carefully! COMPOSITION Ciproxin ® 0.4 g: 1 vial of 200 ml infusion solution contains 400 mg ciprofloxacin. PROPERTIES Pharmacotherapeutic group: Fluoroquinolones ATC Code: J01MA02 Ciprofloxacin is a new substance developed by Bayer AG belon ging to the quinolone carboxylic acid group. The substan ce has a good bactericidal effect against a broad spectrum of bacteria. MECHANISM OF ACTION The bactericidal action of ciprofloxacin results from inhibition of bacterial type II topoisomerases (DNA g yrase and topoisomerase IV), which are required for bacterial DNA replication, transcription, repair, and recombination MECHANISM OF RESISTANCE _In-vitro _resistance to ciprofloxacin can be acquired through a stepwise process by target site mutations in both DNA g yrase and topoisomerase IV. The degree of cross-resistance between ciprofloxacin and other fluoroquinolones that results is variable. Single mutations may not result in clinical resistance, but multiple mutations generally result in clinical resistance to many or all active substances within the class. Impermeability and/or active substance efflux pump mechanisms of resistance may have a variable effect on suscepti bi l i ty to fluoroquinolones, which depends on the physiochemical properties of the vario us active substances within the class an d the affinity of transport systems for each active substance. All _in-vitro _mechanisms of resistance are commonly observed i n clinical isolates. Resistance mechanisms that inactivate other antibiotics such as permeation barriers (common in _Pseudomonas aeruginosa_) and efflux mechanisms may affect susceptibility to ciprofloxacin. Plasmid-mediated resistance encoded by qnr-genes has been reported. The bacterial genus and species listed below have been shown to commonly be susceptible to ciprofloxacin in vitro: AEROBIC GRAM-POSITIVE MICROORGANISMS _Bacillus anthracis _ _St קרא את המסמך השלם