מדינה: אוסטרליה
שפה: אנגלית
מקור: Department of Health (Therapeutic Goods Administration)
Oxybutynin hydrochloride
Sanofi-Aventis Australia Pty Ltd
Medicine Registered
DITROPAN 1 DITROPAN DIT-RO(H)-PAN) _oxybutynin hydrochloride (oxy-BEAUT-in-in HIGH-dro(h)-CLOR-ride)_ CONSUMER MEDICINE INFORMATION (CMI) WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Ditropan. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor or pharmacist has weighed the risks of you taking Ditropan against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT DITROPAN IS USED FOR Ditropan is used to decrease the urgency and the frequency of urination. Ditropan works by relaxing the bladder smooth muscle and helps to decrease muscle spasm. This delays the initial desire and the urge to urinate. Your doctor may have prescribed Ditropan for another reason. ASK YOUR DOCTOR OR PHARMACIST IF YOU HAVE ANY QUESTIONS ABOUT WHY DITROPAN HAS BEEN PRESCRIBED FOR YOU. There is no evidence that Ditropan is addictive. This medicine is available only with a doctor's prescription. Ditropan is not recommended for use in children under the age of 5 years, as there have been no studies of its effects in children. BEFORE YOU TAKE IT _WHEN YOU MUST NOT TAKE IT_ DO NOT TAKE DITROPAN IF YOU HAVE AN ALLERGY TO DITROPAN OR ANY OF THE INGREDIENTS LISTED AT THE END OF THIS LEAFLET. DO NOT TAKE DITROPAN IF YOU HAVE: * angle closure glaucoma or shallow anterior chamber - disorders of the eye * partial or complete intestinal blockage; stomach, intestinal or large bowel problems including colitis (inflammation of the colon) * myasthenia gravis - a disease of the muscles * urinary tract blockage * severe bleeding DO NOT TAKE DITROPAN IF YOU ARE PREGNANT OR INTEND TO BECOME PREGNANT. The safety of the use קרא את המסמך השלם
ditropan-ccsdsv2-piv8-d1-17jan13 1 PRODUCT INFORMATION DITROPAN _ _ NAME OF THE MEDICINE Each tablet contains oxybutynin hydrochloride 5 mg. The chemical structure of oxybutynin hydrochloride is the following: CAS: 1508-65-2 DESCRIPTION Oxybutynin hydrochloride is 4-diethylamino-2-butynyl phenylcyclohexylglycolate hydrochloride. It is a white crystalline solid (MW 393.9), which is readily soluble in water and acids, but relatively insoluble in alkalis. PHARMACOLOGY Oxybutynin hydrochloride exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. Oxybutynin hydrochloride exhibits four to ten times the antispasmodic potency of atropine, but only one fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle. No blocking effects occur at skeletal neuromuscular junctions or autonomic ganglia (antinicotinic effects). Ditropan relaxes bladder smooth muscle. In patients with conditions characterised by involuntary bladder contractions, cystometric studies have demonstrated that Ditropan increases bladder (vesical) capacity, diminishes the frequency of uninhibited contractions of the detrusor muscle, and delays the initial desire to void. Ditropan thus decreases urgency and the frequency of both incontinent episodes and voluntary urination. CLASS Antispasmodic, anticholinergic. PHARMACOKINETICS Oxybutynin hydrochloride is readily absorbed (peak plasma concentration in approx. 1 hour) and rapidly eliminated (plasma half life about 2 hours). Absolute bioavailab קרא את המסמך השלם