עלון מידע
MAGNEVIST
SCHEDULING STATUS:
S2
PROPRIETARY NAME
(and dosage form):
MAGNEVIST
MAGNEVIST 5 mL
MAGNEVIST 10 mL
MAGNEVIST 15 mL
MAGNEVIST 20 mL
MAGNEVIST 30 mL
MAGNEVIST 100 mL
Paramagnetic contrast medium for
magnetic resonance imaging (MRI)
COMPOSITION
1 mL Magnevist contains
gadopentetic acid
(dihydrogen[N,N-bis[2-[bis(carboxymethyl)-amino]ethyl]-glycinate(5-)]
gadolinate (2-), dimeglumine salt 469,01 mg, diethylene triamine pentaacetic acid (DTPA), (3-azapentamethylene
diamine-N,N,N',N'-3-pentaacetic acid) meglumine salt, maximum 1,02 mg in aqueous solution.
Contrast medium concentration
(mg/mL)
469,01
(mol/L)
0,5
Contrast medium content (g) per
5 mL
2,3
10 mL
4,7
15 mL
7,0
20 mL
9,4
30 mL
14,1
100 mL
46,9
Osmolarity at 37°C (osm/L solution) 1,44
Osmolality at 37°C (osm/kg H
2
O)
1,96
Osmotic pressure at 37°C
(atm)
49,8
(MPa)
5,06
Density (kg/L)
at 20°C
1,210
at 37°C
1,195
Viscosity (mPa.s or cP)
at 20°C
4,9
at 37°C
2,9
at 37°C
2,9
pH
6,5-8,0
PHARMACOLOGICAL CLASSIFICATION
A. 28 Contrast media.
PHARMACOLOGICAL ACTION
Magnevist is a paramagnetic contrast medium for use in magnetic resonance imaging (MRI).
The contrast enhancing effect is brought about by the di-N-methylglucamine salt of gadopentetate (Gd-DTPA), the
gadolinium complex of diethylenetriamine pentaacetic acid. The spin-lattice relaxation time of the excited nuclei, which
is shortened
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