Država: Južnoafrička Republika
Jezik: engleski
Izvor: South African Health Products Regulatory Authority (SAHPRA)
Lennon
ARTHREXIN® SUPPOSITORIES SCHEDULING STATUS: S3 PROPRIETARY NAME (and dosage form): ARTHREXIN ® SUPPOSITORIES COMPOSITION: Each suppository contains 100 mg Indomethacin . PHARMACOLOGICAL CLASSIFICATION: A 3.1 Antirheumatics (anti-inflammatory agents) PHARMACOLOGICAL ACTION: Indomethacin has prominent anti-inflammatory and anti-pyretic properties in experimental animals similar to those of the salicylates. Comparable effects have been demonstrated in man. The anti-inflammatory effects of indomethacin are evident in patients with rheumatoid and other types of arthritis and in acute gout. Although indomethacin is more potent than aspirin, the anti-inflammatory effects of tolerated doses of indomethacin in rheumatoid arthritis are not superior to those of salicylate. Whether indomethacin has analgesic properties distinct from its anti-inflammatory effects remains uncertain. However, in patients with acute post-operative and post-traumatic pain of mild to moderate intensity, single doses of indomethacin provide relief approximately equivalent to that of 600 mg of aspirin. The antipyretic effect of indomethacin has also been readily demonstrated in patients with fever. Single doses of indomethacin are usually adequately tolerated; however, because of its potential toxicity, indomethacin is not recommended as a general analgesic-antipyretic. Like the salicylates and related anti-inflammatory agents indomethacin inhibits the biosynthesis of prostaglandins; this action may be the basis of its anti-inflammatory and antipyretic properties and certain of its other effects. Like colchicine, it inhibits motility of polymorphonuclear leucocytes; like salicylate, it uncouples oxidative phosphorylation in cartilaginous and hepatic mitochondria. Indomethacin is rapidly and almost completely absorbed. Peak plasma concentrat Pročitajte cijeli dokument