Država: Južnoafrička Republika
Jezik: engleski
Izvor: South African Health Products Regulatory Authority (SAHPRA)
Aspen-p
ASPEN ESCITALOPRAM SCHEDULING STATUS: S5 PROPRIETARY NAME (and dosage form): ASPEN ESCITALOPRAM ASPEN ESCITALOPRAM 5 mg (film-coated tablet) ASPEN ESCITALOPRAM 10 mg (film coated tablet) ASPEN ESCITALOPRAM 15 mg (film coated tablet) ASPEN ESCITALOPRAM 20 mg (film-coated tablet) COMPOSITION: ASPEN ESCITALOPRAM 5 mg (film-coated tablet) Each film-coated tablet contains Escitalopram Oxalate corresponding to 5 mg Escitalopram . ASPEN ESCITALOPRAM 10 mg (film-coated tablet) Each film-coated tablet contains Escitalopram Oxalate corresponding to 10 mg Escitalopram. ASPEN ESCITALOPRAM 15 mg (film-coated tablet) Each film-coated tablet contains Escitalopram Oxalate corresponding to 15 mg Escitalopram. ASPEN ESCITALOPRAM 20 mg (film-coated tablet) Each film-coated tablet contains Escitalopram Oxalate corresponding to 20 mg Escitalopram. PHARMACOLOGICAL CLASSIFICATION: A 1.2 Psychoanaleptics (antidepressants) PHARMACOLOGICAL ACTION: Pharmacodynamics: Mechanism of action Escitalopram is selective inhibitor of serotonin (5-HT)-uptake. Escitalopram has minimal effect on noradrenaline (NA), dopamine (DA) and gamma aminobutyric acid (GABA) uptake. Escitalopram has no or very low affinity for a series of receptors including 5-HT 1A , 5-HT 2 , DA D 1 and D 2 receptors, alpha 1 -,alpha 2 -,(beta-adrenoceptors, histamine H 1 , muscarine cholinergic, benzodiazepine, and opioid receptors. Pharmakinetics: Absorption Absorption is independent of food intake (mean T max is 4 hours after multiple dosing). Distribution The apparent volume of distribution (V d,beta /F) after oral administration is about 12 to 26 L/kg. The plasma protein binding of escitalopram is approximately 55%. Biotransformation Escitalopram is metabolised in the liver to the demethylated and didemethylated metabolites. Alternatively, the nitrogen may be oxidised to form th Pročitajte cijeli dokument