Država: Australija
Jezik: engleski
Izvor: Department of Health (Therapeutic Goods Administration)
venlafaxine hydrochloride
Generic Health Pty Ltd
Venlafaxine hydrochloride
Registered
[Venlafaxine Sandoz CMI] 1 VENLAFAXINE SANDOZ XR _ _ VENLAFAXINE HYDROCHLORIDE, MODIFIED RELEASE CAPSULES _ _ CONSUMER MEDICINE INFORMATION _ _ VENLAFAXINE SANDOZ XR Venlafaxine Hydrochloride, Modified Release Capsules CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Venlafaxine Sandoz XR capsules. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist or asking questions. All medicines have risks and benefits. Your doctor has weighed the risks of you taking Venlafaxine Sandoz XR against the expected benefits it will have for you. IF YOU HAVE ANY QUESTIONS ABOUT VENLAFAXINE SANDOZ XR, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH YOUR VENLAFAXINE SANDOZ XR CAPSULES. You may need to read it again. WHAT VENLAFAXINE SANDOZ XR IS FOR The name of your medicine is Venlafaxine Sandoz XR. It contains the active ingredient called venlafaxine hydrochloride. Venlafaxine Sandoz XR capsules are used in the treatment and prevention of relapse of depression. Depression can affect your whole body and may cause emotional and physical symptoms such as feeling low in spirit, being unable to enjoy life, poor appetite or overeating, disturbed sleep, loss of sex drive, lack of energy and feeling guilty over nothing. Depression is a treatable illnesses. Anxiety or tension associated with the normal stress of everyday life usually does not require treatment with medicines. Venlafaxine Sandoz XR capsules belong to a class of medications for depression and anxiety, called Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs). Serotonin and noradrenaline are chemical messengers that allow certain nerves in the brain to work. Venlafaxine Sandoz XR capsules increase the level of these two messengers. Experts think this is how it helps to restore your feeling of wellness. [Venlafaxine Sandoz CMI] 2 Venlafaxine Sandoz XR is not addictive. Your doctor may have prescribed Venlafaxine Sandoz XR capsules for another purpos Pročitajte cijeli dokument
Sandoz Pty Ltd Marketed Version 1410 Venlafaxine Sandoz PI v3 Page 1 of 27 PRODUCT INFORMATION VENLAFAXINE SANDOZ XR 75MG/150 MG CAPSULE NAME OF THE MEDICINE Non Proprietary name: Venlafaxine hydrochloride Chemical name: 1-[(1_RS_)-2-( Dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride Molecular formula: C 17 H 27 NO 2 .HCl. MW: 313.87. CAS: 99300-78-4 DESCRIPTION Venlafaxine hydrochloride is a white to off white crystalline solid with a solubility of 572 mg/mL in water (adjusted to ionic strength of 0.2 M with sodium chloride). Venlafaxine Sandoz XR capsules are a modified release formulation which release the active constituent venlafaxine hydrochloride from a tablet(s) within the capsule. Drug is released by a combination of swelling of the hydrophilic polymer (hypromellose), diffusion and erosion. Active. Venlafaxine hydrochloride. Inactive. Hypromellose, sodium lauryl sulfate, magnesium stearate, ammonio methacrylate copolymer and basic butylated methacrylate copolymer. The capsules contain titanium dioxide (E171, CI 77891) and gelatin. The 75mg capsules also contain red iron oxide (E172, CI77491). The 150mg capsules also contain Erythrosine (E127, CI 45430) and Indigo carmine (E132, CI 73015). PHARMACOLOGY Actions Venlafaxine is a structurally novel antidepressant for oral administration; it is chemically unrelated to tricyclic, tetracyclic or other available antidepressant agents. _PHARMACODYNAMICS_ The antidepressant action of venlafaxine in humans is believed to be associated with its potentiation of neurotransmitter activity in the central nervous system. Sandoz Pty Ltd Marketed Version 1410 Venlafaxine Sandoz PI v3 Page 2 of 27 Preclinical studies have shown that venlafaxine and its major metabolite, _O_- desmethylvenlafaxine (ODV), are potent inhibitors of serotonin and noradrenaline reuptake, and also weakly inhibit dopamine reuptake. Venlafaxine is a racemate. The_ R_-enantiomer is relatively more potent than the_ S_-enantiomer with regard to inhibition of noradrenaline reuptake; th Pročitajte cijeli dokument