Ország: Indonézia
Nyelv: indonéz
Forrás: Badan Pengawas Obat dan Makanan RI - Indonesian Food and Drug Supervisory Agency
CANDESARTAN
TAKEDA INDONESIA - Indonesia
CANDESARTAN
8 MG
TABLET
DUS, 4 BLISTER @ 7 TABLET
TAKEDA INDONESIA - Indonesia
2016-07-14
Based on CCDS Candesartan Cilexetil ver. 22.0 dated June 19, 2021. 1 BLOPRESS ® TABLET 8 MG AND 16 MG CANDESARTAN CILEXETIL COMPOSITION Blopress tablets 8 mg are round pale pink tablets with a single score line on one sides. Each tablet contains 8 mg candesartan cilexetil. Blopress tablets 16 mg are round pink tablets with no score. Each tablet contains 16 mg candesartan cilexetil. PHARMACOLOGICAL ACTIONS Angiotensin II is the primary vasoactive hormone of the renin-angiotensin-aldosterone system and plays a significant role in the pathophysiology of hypertension, heart failure and other cardiovascular disorders. It is also has an important role in the pathogenesis of end organ hypertrophy and damage. The major physiological effects of angiotensin II, such as vasoconstriction, aldosterone stimulation, regulation of salt and water homeostasis and stimulation of cell growth, are mediated via the type I (AT 1 ) receptor. Blopress is a prodrug suitable for oral use. It is rapidly converted to the active drug, candesartan, by ester hydrolysis during absorption from the gastrointestinal tract. Blopress is an angiotensin II receptor antagonist, selective for AT 1 receptor, with tight binding to and slow dissociation from the receptor. It has no agonist activity. Candesartan does not inhibit ACE, which convert angiotensin I to angiotensin II and degrades bradykinin. There is no effect on ACE and no potentiation of bradykinin or substance P. In controlled clinical trials comparing Blopress with ACE-inhibitor, the incidence of cough was lower in patients receiving Blopress. Candesartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. _HYPERTENSION _ In hypertension, Blopress causes a dose–dependent, long lasting reduction in arterial blood pressure. The antihypertensive action is due to decreased systemic peripheral resistance, while heart rate, stroke volume and cardiac output are not affected. There is no indication of serious exaggerate first –dos Olvassa el a teljes dokumentumot