Ország: Egyesült Államok
Nyelv: angol
Forrás: NLM (National Library of Medicine)
CARPROFEN (UNII: FFL0D546HO) (CARPROFEN - UNII:FFL0D546HO)
Putney, Inc.
CARPROFEN
CARPROFEN 25 mg
ORAL
PRESCRIPTION
Carprofen Caplets are indicated for the relief of pain and inflammation associated with osteoarthritis in dogs and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. Carprofen Caplets should not be used in dogs exhibiting previous hypersensitivity to carprofen.
Carprofen Caplets 25 mg – Each light orange, convex tablet debossed with "G" on one side and bisected on the other side with "33" on the left and "11" on the right of the bisect. Carprofen Caplets 75 mg – Each light orange, convex tablet debossed with "G" on one side and bisected on the other side with "33" on the left and "22" on the right of the bisect. Carprofen Caplets 100 mg – Each light orange, convex tablet debossed with "G" on one side and bisected on the other side with "33" on the left and "33" on the right of the bisect.
Abbreviated New Animal Drug Application
CARPROFEN- CARPROFEN TABLET PUTNEY, INC. ---------- CARPROFEN CAPLETS 25 MG, 75 MG AND 100 MG NON-STEROIDAL ANTI-INFLAMMATORY DRUG FOR ORAL USE IN DOGS ONLY CAUTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and ketoprofen. The chemical name for carprofen, a substituted carbazole, is 6- chloro- alpha-methyl-9H-carbazole-2-acetic acid. The empirical formula is C H ClNO and the molecular weight 273.72. The chemical structure of carprofen is shown above. Carprofen is a white, crystalline compound. It is freely soluble in ethanol, but practically insoluble in water at 25°C. CLINICAL PHARMACOLOGY Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent with characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models. The mechanism of action of carprofen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity. The specificity of a particular NSAID for COX-2 versus COX-1 may vary from species to species. In an_ in vitro _study using canine cell cultures, carprofen demonstrated selective inhibition of COX-2 versus COX-1. Clinical relevance of these data has not been shown. Carprofen has also been shown to inhibit the release of several prostaglandins in two inflammatory cell systems: rat polymorphonuclear leukocytes (PMN) and human rheumatoid synovial cells, indicating inhibition of acute (PMN system) and chronic (synovial ce Olvassa el a teljes dokumentumot