Ország: Egyesült Államok
Nyelv: angol
Forrás: NLM (National Library of Medicine)
hyaluronate sodium (UNII: YSE9PPT4TH) (hyaluronic acid - UNII:S270N0TRQY)
Merial, Inc.
hyaluronate sodium
hyaluronate sodium 10 mg in 1 mL
INTRAVENOUS
PRESCRIPTION
INDICATIONS: LEGEND Multi Dose Injectable Solution is indicated in the treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis. CONTRAINDICATIONS: There are no known contraindications for the use of LEGEND Multi Dose Injectable Solution in horses.
HOW SUPPLIED: LEGEND Multi Dose Injectable Solution is supplied in 20 mL bottles.
New Animal Drug Application
LEGEND MULTI DOSE- HYALURONATE SODIUM INJECTION, SOLUTION MERIAL, INC. ---------- LEGEND MULTI DOSE (HYALURONATE SODIUM) INJECTABLE SOLUTION FOR INTRAVENOUS USE IN HORSES ONLY NOT FOR INTRA-ARTICULAR USE CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: LEGEND Multi Dose Injectable Solution is a clear, colorless solution of low viscosity. LEGEND Multi Dose Injectable Solution is pyrogen free and sterile. It is administered by intravenous injection. Hyaluronic acid, the conjugate acid of hyaluronate sodium, is extracted from the capsule of _Streptococcus_ spp. and purified, resulting in a form which is essentially free of protein and nucleic acids. LEGEND Multi Dose Injectable Solution is supplied in 20 mL vials. Each mL contains 10 mg hyaluronate sodium, 8.5 mg sodium chloride, 0.223 mg sodium phosphate dibasic, 0.04 mg sodium phosphate monobasic and 15.63 mg benzyl alcohol as a preservative. The pH is adjusted to between 6.5 and 8.0 with sodium hydroxide or hydrochloric acid. CHEMISTRY: Hyaluronic acid, a glycosaminoglycan, can exist in the following forms depending upon the chemical environment in which it is found: as the acid, hyaluronic acid; as the sodium salt, sodium hyaluronate (hyaluronate sodium); or as the hyaluronate anion. These terms may be used interchangeably but in all cases, reference is made to the glycosaminoglycan composed of repeating subunits of D-glucuronic acid and N-acetyl- D-glucosamine linked together by glycosidic bonds. Since this product originates from a microbial source, there is no potential for contamination with dermatan or chondroitin sulfate or any other glycosaminoglycan. CLINICAL PHARMACOLOGY: Hyaluronic acid is a naturally occurring substance present in connective tissue, skin, vitreous humour and the umbilical cord in all mammals. High concentrations of hyaluronic acid are also found in the synovial fluid. It also constitutes the major component of the capsule of certain microorganisms. The hyaluronic acid produced Olvassa el a teljes dokumentumot