AMOXICILLIN AND CLAVULANATE POTASSIUM powder, for suspension

Negara: Amerika Serikat

Bahasa: Inggris

Sumber: NLM (National Library of Medicine)

Bahan aktif:

AMOXICILLIN (UNII: 804826J2HU) (AMOXICILLIN ANHYDROUS - UNII:9EM05410Q9), CLAVULANATE POTASSIUM (UNII: Q42OMW3AT8) (CLAVULANIC ACID - UNII:23521W1S24)

Tersedia dari:

Dechra Veterinary Products LLC

Rute administrasi :

ORAL

Jenis Resep:

PRESCRIPTION

Indikasi Terapi:

Amoxicillin and Clavulanate Potassium for Oral Suspension drops are indicated in the treatment of: Dogs: Skin and soft tissue infections such as wounds, abscesses, cellulitis, superficial/juvenile and deep pyoderma due to susceptible strains of the following organisms: β-lactamase-producing Staphylococcus aureus, non-β-lactamase-producing Staphylococcus aureus , Staphylococcus spp., Streptococcus spp., and E. coli . Periodontal infections due to susceptible strains of both aerobic and anaerobic bacteria. Amoxicillin and Clavulanate Potassium for Oral Suspension has been shown to be clinically effective for treating cases of canine periodontal disease. Cats: Skin and soft tissue infections such as wounds, abscesses, and cellulitis/dermatitis due to susceptible strains of the following organisms: β-lactamase-producing Staphylococcus aureus , non-β-lactamase-producing Staphylococcus aureus , Staphylococcus spp., Streptococcus spp., E. coli , Pasteurella multocida , and Pasteurella spp. Urinary tract infe

Ringkasan produk:

Amoxicillin and Clavulanate Potassium for Oral Suspension drops are supplied in 22-mL bottles containing 50 mg of amoxicillin/12.5 mg of clavulanic acid per mL.

Status otorisasi:

Abbreviated New Animal Drug Application

Karakteristik produk

AMOXICILLIN AND CLAVULANATE POTASSIUM- AMOXICILLIN AND CLAVULANATE
POTASSIUM POWDER, FOR SUSPENSION
DECHRA VETERINARY PRODUCTS LLC
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AMOXICILLIN AND CLAVULANATE POTASSIUM
FOR ORAL SUSPENSION
DROPS
_For veterinary oral suspension_
_For use in dogs and cats_
CAUTION:
Federal (USA) law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION:
Amoxicillin and Clavulanate Potassium for Oral Suspension is an orally
administered
formulation comprised of the broad-spectrum antibiotic amoxicillin
trihydrate and the β-
lactamase inhibitor, clavulanate potassium (the potassium salt of
clavulanic acid).
Amoxicillin trihydrate is a semisynthetic antibiotic with a broad
spectrum of bactericidal
activity against many Gram-positive and Gram-negative, aerobic and
anaerobic
microorganisms. It does not resist destruction by β-lactamases;
therefore, it is not
effective against β-lactamase-producing bacteria. Chemically, it is
D(-)-α-amino-p-
hydroxybenzyl penicillin trihydrate.
Clavulanic acid, an inhibitor of β-lactamase enzymes, is produced by
the fermentation of
_Streptomyces clavuligerus_. Clavulanic acid by itself has only weak
antibacterial activity.
Chemically, clavulanate potassium is potassium
z-(3R,5R)-2-β-hydroxyethylidene clavam-
3-carboxylate.
CLINICAL PHARMACOLOGY:
Amoxicillin and Clavulanate Potassium for Oral Suspension is stable in
the presence of
gastric acid and is not significantly influenced by gastric or
intestinal contents. The 2
components are rapidly absorbed resulting in amoxicillin and
clavulanic acid
concentrations in serum, urine, and tissues similar to those produced
when each is
administered alone.
Amoxicillin and clavulanic acid diffuse readily into most body tissues
and fluids with the
exception of brain and spinal fluid, which amoxicillin penetrates
adequately when
meninges are inflamed. Most of the amoxicillin is excreted unchanged
in the urine.
Clavulanic acid's penetration into spinal fluid is unknown at this
time. Approximately 15%
of the administered