Negara: Amerika Serikat
Bahasa: Inggris
Sumber: NLM (National Library of Medicine)
MECHLORETHAMINE HYDROCHLORIDE (UNII: L0MR697HHI) (MECHLORETHAMINE - UNII:50D9XSG0VR)
RECORDATI RARE DISEASES, INC.
MECHLORETHAMINE HYDROCHLORIDE
MECHLORETHAMINE HYDROCHLORIDE 10 mg in 10 mL
PRESCRIPTION DRUG
New Drug Application
MUSTARGEN- MECHLORETHAMINE HYDROCHLORIDE POWDER, FOR SOLUTION RECORDATI RARE DISEASES, INC. ---------- TRITURATION OF MUSTARGEN (MECHLORETHAMINE HCL FOR INJECTION) RX ONLY WARNINGS MUSTARGEN (mechlorethamine HCl) should be administered only under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents. This drug is HIGHLY TOXIC and both powder and solution must be handled and administered with care. Inhalation of dust or vapors and contact with skin or mucous membranes, especially those of the eyes, must be avoided. Avoid exposure during pregnancy. Due to the toxic properties of mechlorethamine (e.g., corrosivity, carcinogenicity, mutagenicity, teratogenicity), special handling procedures should be reviewed prior to handling and followed diligently. Extravasation of the drug into subcutaneous tissues results in a painful inflammation. The area usually becomes indurated and sloughing may occur. If leakage of drug is obvious, prompt infiltration of the area with sterile isotonic sodium thiosulfate (1/6 molar) and application of an ice compress for 6 to 12 hours may minimize the local reaction. For a 1/6 molar solution of sodium thiosulfate, use 4.14 g of sodium thiosulfate per 100 mL of Sterile Water for Injection or 2.64 g of anhydrous sodium thiosulfate per 100 mL or dilute 4 mL of Sodium Thiosulfate Injection (10%) with 6 mL of Sterile Water for Injection. DESCRIPTION MUSTARGEN, an antineoplastic nitrogen mustard also known as HN2 hydrochloride, is a nitrogen analog of sulfur mustard. It is a light yellow brown, crystalline, hygroscopic powder that is very soluble in water and also soluble in alcohol. Mechlorethamine hydrochloride is designated chemically as 2-chloro- _N_-(2-chloroethyl)- _N_-methylethanamine hydrochloride. The molecular weight is 192.52 and the melting point is 108-111°C. The empirical formula is C H Cl N•HCl, and the structural formula is: CH N(CH CH Cl) •HCl. Trituration of MUSTARGEN is a sterile, light yellow brown crystalline powder for injection Baca dokumen lengkapnya