Negara: Indonesia
Bahasa: Bahasa Indonesia
Sumber: Badan Pengawas Obat dan Makanan RI - Indonesian Food and Drug Supervisory Agency
BAYER INDONESIA - Indonesia -
2 MG
TABLET SALUT GULA
ESTRADIOL VALERATE
DUS, 1 BLISTER @ 28 TABLET SALUT GULA
Obat
BAYER WEIMAR GMBH UND CO. KG - Federal Republic of Germany
Berlakus/d 29-03-2028
2023-03-29
Name of Product/Active ingredient/Dosage form/Version/Date of approval Progynova/Estradiol valerate/Sugar coated tablet/Deletion Shelf-life info 1 PROGYNOVA ® 2 MG SUGAR COATED TABLETS Important information, please read carefully! COMPOSITION Each white sugar-coated tablet contains estradiol valerate 2.0 mg. PHARMACOLOGICAL PROPERTIES Pharmacotherapeutic group: Natural and semisynthetic estrogen, plain ATC Code: G03CA03 Progynova contains the estrogen estradiol valerate, a prodrug of the natural human 17ß- estradiol. Ovulation is not inhibited during the use of Progynova, and the endogenous production of hormones is hardly affected. During the climacteric, the reduction and finally loss of ovarian estradiol secretion can result in instability of thermoregulation, causing hot flushes associated with sleep disturbance and excessive sweating, and urogenital atrophy with symptoms of vaginal dryness, dyspareunia and urinary incontinence. Less specific but often mentioned as part of the climacteric syndrome are symptoms like anginal complaints, palpitations, irritability, nervousness, lack of energy and concentration abilities, forgetfulness, loss of libido and joint and muscle pain. Hormone replacement therapy (HRT) alleviates many of these symptoms of estradiol deficiency in the menopausal woman. HRT with an adequate estrogen dosage like in Progynova 2 mg reduces bone resorption and retards or halts postmenopausal bone loss. When HRT is discontinued, bone mass declines at a rate comparable to that in the immediate postmenopausal period. There is no evidence that HRT restores bone mass to premenopausal levels. HRT also has a positive effect on skin collagen content and skin thickness and can retard the process of skin wrinkling. HRT changes the lipid profile. It lowers total cholesterol and LDL-cholesterol and may increase HDL- cholesterol and triglyceride levels. The metabolic effects may be counteracted to some extent by the addition of a progestogen. The addition of a progestogen to an estrogen replacement regime Baca dokumen lengkapnya