Negara: Afrika Selatan
Bahasa: Inggris
Sumber: South African Health Products Regulatory Authority (SAHPRA)
Lennon
PURATA - 10 TABLETS PURATA - 15 TABLETS PURATA - 30 TABLETS SCHEDULING STATUS: S5 PROPRIETARY NAME (and dosage form): PURATA - 10 TABLETS PURATA - 15 TABLETS PURATA - 30 TABLETS COMPOSITION: Each tablets contains 10 (15, 30) mg of Oxazepam PHARMACOLOGICAL CLASSIFICATION: A 2.6 - Tranquillizers PHARMACOLOGICAL ACTION: Oxazepam is a benzodiazepine derivative with sedative properties. It is a N-demethylated 3-hydroxylated metabolic product of diazepam. Some muscle relaxation occurs after administration in high dosage. Oxazepam reaches a peak plasma concentration in 4 hours and is excreted in the urine as the glucuronide conjugate. Oxazepam is absorbed from the gastro-intestinal tract. Up to 80% of a dose is excreted in the urine over 72 hours, about 10% of a dose or less has been recovered from the faeces as free oxazepam. INDICATIONS: Oxazepam is used in the treatment of anxiety and tension and to relieve the acute symptoms of the alcohol withdrawal syndrome. Oxazepam is only indicated when the disorder is severe, disabling or subjecting the individual to extreme stress. CONTRA-INDICATIONS: Oxazepam should not be given to psychotic patients and in those suffering from mental depression or suicidal tendencies. Caution should be observed when giving oxazepam to elderly or debilitated patients who are specially sensitive to its side-effects, to patients with renal or hepatic dysfunction, and to patients with closed-angle glaucoma. Oxazepam is contra-indicated in infants and in patients with known hypersensitivity to oxazepam and other benzodiazepines. Pre-existing CNS depression or coma is normally a contra-indication. Use of oxazepam in the first trimester of pregnancy has been associated with various congenital malformations in the infant and in the last trimester it has been Baca dokumen lengkapnya