Negara: Malaysia
Bahasa: Inggris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
TOLFENAMIC ACID
Gladron Chemicals Sdn Bhd
TOLFENAMIC ACID
10.00 mcg/mL
Vetoquinol
TOLFEDINE ® 4% W/V SOLUTION FOR INJECTION FOR USE IN DOGS AND CATS _DIMENSIONS : 160x120 mm _ _RÉFÉRENCE ARTICLE : XXXXXX 0611 B_ _NOM DU PRODUIT :_ _Notice Tolfédine 4% Malaysie_ _1 COULEUR_ _281 U_ _CRÉÉ PAR : A.Milleret_ _LE : _ _VISA :_ _REV B_ _VÉTOQUINOL _ NON STEROIDAL ANTI-INFLAMMATORY - ANALGESIC - ANTIPYRETIC Each ml contains tolfenamic acid 40mg as active ingredient with benzyl alcohol 10.4mg and sodium formaldehyde sulphoxylate dihydrate 5mg as preservative. USES Cats: Adjuvant treatment of upper respiratory disease in association with anti- microbial therapy Dogs: Inflammatory and painful post-operative syndromes PHARMACODYNAMIC PROPERTIES Tolfenamic acid (N-52-methyl-3-chloropentyl) anthranilic acid) is belonging to the fenamate group. Substances of this group exert antiinflammatory, analgesic and antipyretic activities. Fenamates are classified as non steroidal antiinflammatory drug (NSAID). the antiinflammatory activity of tolfenamic acid is mainly due to an inhibition of cyclooxygenase and thus a reduction of the synthesis of prostaglandins, important inflammatory mediator. PHARMACOKINETIC PARTICULARS The pharmacokinetics of tolfenamic acid have been investigated in laboratory animals, in man and in the target species, dogs and cats. ABSORPTION In the dogs, tolfenamic acid is readily absorbed either by oral or by injectable administration. By oral route, Cmax of about 4 μg / ml is attained after about 1 hour at the single dose of 4 mg / kg. When administering at the same dose during the meal tolfenamic acid Cmax is of 2 ± 3 μg /ml. These variation can be accounted for a greater enterohepatic recycling when administered with food. By injectable route, the maximum plasma concentration of about 4 μg / ml (s.c.) and about 3 μg / ml (i.m.) are obtained 2 hours after administration of 4 mg / kg i.m. as well as s.c. In the cats, the absorption is quite rapid. By oral route, after a dose of 4 mg/ kg a mean maximum concentration of about 5.6 μg / ml is attained . The mean Tmax is observed aft Baca dokumen lengkapnya