Amlovas Tablet 10mg

国: マレーシア

言語: 英語

ソース: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

有効成分:

AMLODIPINE BESILATE

から入手可能:

ANTAH PHARMA SDN. BHD.

INN（国際名）:

AMLODIPINE BESILATE

パッケージ内のユニット:

30Tablet Tablets

製:

Drogsan Ilaclari San.ve Tic.A.S

情報リーフレット

PATIENT INFORMATION LEAFLET
AMLOVAS 5 MG TABLET/AMLODIPINE
BESILATE
AMLOVAS 10 MG TABLET/AMLODIPINE
BESILATE WHAT IS IN THIS LEAFLET
What AMLOVAS is used for
How AMLOVAS works
Before you use AMLOVAS
How to take AMLOVAS
While you are using AMLOVAS
Side effects
After using AMLOVAS
Product description
Manufacturer
Marketing authorization holder
WHAT AMLOVAS IS USED FOR
AMLOVAS belongs to a group of medicines
called calcium antagonists.
AMLOVAS is used to treat:
- high blood pressure
- chest pain due to narrowing of the blood
vessels
of
the
heart
muscle
(angina
pectoris) or the more rare form of chest pain
caused by cramping of the blood vessels of
the heart muscle .
HOW AMLOVAS WORKS
If you suffer from high blood pressure,
AMLOVAS
works
by
relaxing
blood
vessels, so that blood passes through them
more easily.
If
you
suffer
from
angina, AMLOVAS
works by improving blood supply to the
heart muscle which then receives more
oxygen
and
as
a
result
chest
pain
is
prevented. AMLOVAS does not provide
immediate relief of chest pain from angina.
BEFORE YOU USE AMLOVAS
YOU MUST NOT TAKE AMLOVAS,
if you
-
are
allergic
to
amlodipine
or
similar
calcium channel blockers (the so-called
dihydropyridine derivates like felodipine,
nifedipine, nimodipine) or to any of the
other
ingredients
(for
a
full
list
of
ingredients, see
_Product description_
).
- are suffering from cardiogenic shock.
This
is
a
condition
where
the
heart
is
unable
to pump sufficient blood around the body.
The symptoms of cardiogenic shock are
low blood pressure, low pulse and fast
heartbeat.
- are suffering from narrowing of the aorta
(aortic stenosis).
- suffer from chest pain at rest or with
minimal effort (unstable angina pectoris).
- are pregnant or breast-feeding.
- have severe low blood pressure.
BEFORE YOU START TO TAKE AMLOVAS,
tell
your doctor if you
- have heart failure or have suffered a heart
attack during the past month.
- have liver problems
- are giving this medicine to a child under 18
years of age
- are elderly, your doctor may monitor you
closely.
T

製品の特徴

PRESENTATION
Tab 10 mg x 30’s
DESCRIPTION
Each round white tablet contains 13,889 mg of
Amlodipine besylate equivalent to 10 mg Amlodipine
base and as excipients microcrystalline cellulose, dibasic
calcium phosphate anhydrous, sodium starch glycolate
and magnesium stearate.
PHARMACOLOGICAL PROPERTIES
Pharmacodynamic properties
Amlodipine is a calcium ion influx inhibitor (slow channel
or calcium antagonist) and inhibits the transmembrane
influx of calcium ion into the cardiac and vascular smooth
muscle.
The mechanism of the hypertensive action of amlodipine
is due to a direct relaxant effect on the vascular smooth
muscle. The precise mechanism by which amlodipine
relieves angina has not been fully determined, but
amlodipine reduces to the total ischemic burden by the
following 2 actions:
1. Amlodipine dilates the peripheral arteriols and thus,
reduces the total peripheral resistance (afterload) against
which the heart works. Since the heart rate remains
stable, this unloading of the heart reduces myocardial
energy consumption and oxygen requirements.
2. The mechanism of action of amlodipine probably
involves dilation of the main coronary arteries and
coronary arteriols, both normal and ischemic regions.
This dilatation increases myocardial oxygen delivery in
patients with coronary artery spasm (Prinzental’s or
variant angina) and blunts smoking-induced coronary
vasoconstriction.
In patients with hypertension, once-daily dosing provides
clinically significant reductions of blood pressure in both
the supine and standing positions throughout the 24-hr
interval. Due to the slow onset of action, acute
hypotension is not a feature of amlodipine administration.
In patients with angina, once-daily administration of
amlodipine increases total exercise time, time to angina
onset, and time to 1 mm ST segment depression and
decreases both angina attack frequency and
nitroglycerine tablet consumption. Amlodipine has not
been associated with any adverse metabolic effects or
changes in plasma lipids and is suitable for use