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MELOXICAM RANBAXY
Meloxicam Ranbaxy CMI V3 May 2010
Page 1 of 4
_MELOXICAM TABLETS_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some
common questions about
MELOXICAM RANBAXY. It does not
contain all available information,
nor does it take the place of
talking to your doctor or
pharmacist.
Keep this leaflet with this
medicine. You may need to read it
again later.
You should ask your doctor or
pharmacist if you have any
questions about MELOXICAM
RANBAXY or if you have any
trouble before, during or after
taking MELOXICAM RANBAXY.
WHAT MELOXICAM RANBAXY IS
USED FOR
MELOXICAM RANBAXY is used to
treat the symptoms of:
osteoarthritis
rheumatoid
arthritis
Although MELOXICAM RANBAXY
can relieve symptoms such as
pain and inflammation, it will not
cure your condition.
MELOXICAM RANBAXY belongs to a
family of medicines called Non-
Steroidal Anti-inflammatory Drugs
(NSAIDs). These medicines work
by relieving pain and
inflammation.
Ask your doctor if you have any
questions about why MELOXICAM
RANBAXY has been prescribed for
you. Your doctor may have
prescribed MELOXICAM RANBAXY
for another reason.
BEFORE YOU TAKE MELOXICAM
RANBAXY
WHEN YOU MUST NOT TAKE
MELOXICAM RANBAXY
Do not take MELOXICAM RANBAXY
if you have an allergy to:
- the active ingredient,
meloxicam, lactose or any of
the other ingredients in
MELOXICAM RANBAXY (all of
these ingredients are listed at
the end of this leaflet)
- aspirin or any other NSAID
medicine
Some of the symptoms of an
allergic reaction may include:
rash, itching or hives on the
skin
swelling of the face, lips,
tongue or other parts of the
body
shortness of breath, wheezing
or trouble breathing
If you are not sure if you have
these allergies, you should raise
those concerns with your d
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Ranbaxy Australia Pty Ltd
Meloxicam Ranbaxy PI
MELOXICAM RANBAXY PI V2 May10
Page 1 of 16
MELOXICAM RANBAXY PRODUCT INFORMATION
COMPOSITION
Meloxicam
DESCRIPTION
Chemical
names: 4-hydroxy-2-methyl-_N_-(5-methyl-2-thiazolyl)-2_H_-1,2-benzothiazine-3-
carboxamide-1,1-dioxide and 2_H_-1,2-benzothiazine-3-carboxamide,4-hydroxy-2-methyl-_N_-(5
methyl-2-thiazolyl)-1,1-dioxide.
Molecular formula: C
14
H
13
N
3
O
4
S
2
.
MW: 351.4.
CAS: 71125-38-7.
Meloxicam is a pale yellow powder with pKa values
of 1.09 and 4.18 and a melting point of about
256 deg. C. The substance is practically insoluble
in water, soluble in dimethylformamide, slightly
soluble in chloroform and acetone and very slightly soluble in
methanol. There are no chiral
centres and no polymorphs are formed under normal conditions.
Meloxicam Ranbaxy tablets contain the following excipients:
microcrystalline cellulose,
pregelatinised maize starch, lactose, starch- maize, sodium
citrate, silica colloidal anhydrous,
magnesium stearate.
PHARMACOLOGY
Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) of
the enolic acid class, which has
shown anti-inflammatory, analgesic and antipyretic
properties in animals. Meloxicam showed anti-
inflammatory activity in all standard models of inflammation.
A common mechanism for the above
effects may exist in the ability of meloxicam to inhibit the
biosynthesis of prostaglandins, known
mediators of inflammation,
by inhibition of cyclooxygenase (COX).
Comparison of the ulcerogenic dose and
the anti-inflammatory effective dose in rat adjuvant
arthritis confirmed a greater therapeutic margin in
animals over other NSAIDs (piroxicam,
diclofenac, naproxen, flurbiprofen). In rats,
meloxicam showed greater inhibitory effect on
prostaglandin biosynthesis at the site of inflammation than in
the gastric mucosa or the kidney.
Selective i
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