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PHENOBARBITONE ELIXIR
_Phenobarbitone 15mg in 5mL _
_ _
CONSUMER MEDICINE INFORMATION
IMPORTANT INFORMATION
ABOUT YOUR MEDICINE
Phenobarbitone Elixir 15mg/5mL
Page 1 of 4
This medicine the doctor has
prescribed for you is called
Phenobarbitone Elixir.
The information in this leaflet
will answer some of the
questions you may have about
Phenobarbitone Elixir. This
leaflet does not tell you
everything. Your doctor or
pharmacist has been provided
with full information and can
answer any questions you may
have.
This leaflet does not replace
the advice given to you by your
doctor. Talk to your doctor or
pharmacist.
You should read this leaflet
before taking Phenobarbitone
Elixir and keep it in a safe place
to refer to later.
WHAT PHENOBARBITONE
ELIXIR IS USED FOR
Phenobarbitone Elixir is used to
treat people with epilepsy. It is
a barbiturate which belongs to
a group of medicines called
central nervous system
depressants (medicines that
cause drowsiness). Your
doctor however may have
prescribed Phenobarbitone
Elixir for another purpose. Ask
you doctor if you have any
questions about why
Phenobarbitone Elixir has been
prescribed for you.
BEFORE TAKING THIS
MEDICINE
When deciding to take a
medicine, the risks of taking the
medicine must be weighed
against the good it will do. This
is a decision you and your
doctor will make. For
barbiturates the following
should be considered:
_ALLERGIES_: Tell your doctor if
you have ever had any unusual
or allergic reactions to
phenobarbitone or barbiturates,
or any of the ingredients in
Phenobarbitone Elixir (see
PRODUCT DESCRIPTION).
Symptoms of an allergic
reaction may include red itchy
skin rashes, difficulty breathing,
hay fever, swelling of the face,
lips, tongue or other parts of
the body. Tell your doctor if
you are allergic to any other
substances s
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PRODUCT INFORMATION
PHENOBARBITONE ELIXIR 15MG/5ML
NAME OF THE DRUG
Phenobarbitone
_CHEMICAL STRUCTURE _
DESCRIPTION Phenobarbitone is a barbituric acid derivative. It
occurs as colourless crystals or
a white odourless crystalline powder. Soluble 1 in 1000 of water
and 1 in 10 of alcohol. It is
soluble in alcohol, in ether and in solutions of fixed alkali
hydroxides and carbonates, it is
sparingly soluble in chloroform. Phenobarbitone is
5-ethyl-5-phenylbarbituric acid and has
the molecular formula C
12
H
12
N
2
O
3
and molecular weight 232.2.
CAS number 50-06-6
Phenobarbitone Elixir contains 15mg phenobarbitone per 5mL (0.3%w/v)
in a sweetened
sucrose free base. It contains butterscotch flavour,
ethanol, glycerol, sorbitol solution (70%
non-crystallising) and water.
PHARMACOLOGY
_ACTIONS _Phenobarbitone is a non selective
central nervous system depressant with a long
duration of action. The mechanism of action of the
barbiturates is not completely known.
They may act by enhancing and/or mimicking the synaptic action
of gamma-aminobutyric acid
(GABA). Barbiturates depress the sensory cortex, decrease motor
activity, alter cerebellar
function and produce drowsiness, sedation and hypnosis.
Phenobarbitone is reported to have
anti convulsant activity at sub-hypnotic doses._ _
The anticonvulsant properties are believed to be due to depression of
mono-synaptic and
poly-synaptic transmission and increasing the threshold for
electrical stimulation of the motor
cortex.
PHARMACOKINETICS
_ABSORPTION _Phenobarbitone is readily
absorbed (about 70-90% of an oral dose) from the
gastrointestinal tract. It is relatively lipid insoluble and may
require up to an hour or longer to
achieve effective concentrations. Absorption is increased if
barbiturates are taken well diluted
or on an empty stomach. Its duration of action ranges from 10-12
hours.
_
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