Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
AMLODIPINE BESILATE
LABORATORIES TORRENT (MALAYSIA) SDN. BHD.
AMLODIPINE BESILATE
10tablet Tablets; 100tablet Tablets; 30tablet Tablets
TORRENT PHARMACEUTICALS LTD
AMLOCOR TABLET _ _ Amlodipine Besilate 5mg _ _ _ _ 1 _ _ _ CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET 1. What is AMLOCOR used for 2. How AMLOCOR works 3. Before you use AMLOCOR 4. How to use AMLOCOR 5. While you are using it 6. Side effects 7. Storage and Disposal of AMLOCOR 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision 11. Serial Number WHAT AMLOCOR IS USED FOR Amlocor can be used to treat high blood pressure (hypertension) or a myocardial ischemia, whether due to fixed obstruction (stable angina) and/or vasospasm / vasoconstriction (Prinzmetal's or variant angina). HOW AMLOCOR WORKS In patients with high blood pressure your medicine works by relaxing blood vessels, so that blood passes through them more easily. In patients with angina Amlocor works by improving blood supply to the heart muscle which then receives more oxygen and as a result myocardial ischemia is prevented. BEFORE YOU USE AMLOCOR - _When you must not use it _ If you are allergic (hypersensitive) to Amlocor, or any of the other ingredients of your medicine (listed below in Ingredients section of Product Description), or to any other calcium antagonists. This may cause itching, reddening of the skin or difficulty in breathing. Do not take Amlocor if the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking Amlocor _Pregnancy and lactation _ _ _ _ _ _PREGNANCY _ The safety of Amlocor in human pregnancy has not been reported. If you think you might be pregnant, or are planning to get pregnant, you must tell your doctor before you take Amlocor. _BREAST-FEEDING _ It is not known whether Amlocor is passed into breast milk. If you are breast-feeding or about to start breast- feeding you must tell your doctor before taking Amlocor.. - _Before you start use it _ Before you take Amlocor, tell your doctor if: • Recent heart attack • Heart failure • Impaired Liver Function - _Taking other medicines _ Please tell your doctor or pharmacist if Baca dokumen lengkap
xxxxxxxx-5253 BRAND OR PRODUCT NAME AMLOCOR TABLETS 5 MG NAME AND STRENGTH OF ACTIVE SUBSTANCE(S) Each uncoated tablet contains: Amlodipine Besilate Ph. Eur. equivalent to Amlodipine …………… 5 mg PRODUCT DESCRIPTION White, round, flat uncoated tablets, debossed with ‘5’ on one side of tablets and bisecting line on the other side. DOSAGE FORM Uncoated tablet PHARMACODYNAMICS / PHARMACOKINETICS PHARMACODYNAMICS Amlodipine is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. The mechanism of the antihypertensive action of amlodipine is due to a direct relaxant effect on vascular smooth muscle. The precise mechanism by which amlodipine relieves angina has not been fully determined but amlodipine reduces total ischemic burden by the following two actions. 1. Amlodipine dilates peripheral arterioles and thus, reduces the total peripheral resistance (afterload) against which the heart works. Since the heart rate remains stable, this unloading of the heart reduces myocardial energy consumption and oxygen requirements. 2. The mechanism of action of amlodipine also probably involves dilatation of the main coronary arteries and coronary arterioles, both in normal and ischemic regions. This dilatation increases myocardial oxygen delivery in patients with coronary artery spasm (Prinzmetal's or variant angina) and blunts smoking induced coronary vasoconstriction. In patients with hypertension, once daily dosing provides clinically significant reductions of blood pressure in both the supine and standing positions throughout the 24 hour interval. Due to the slow onset of action, acute hypotension is not a feature of amlodipine administration. It was reported that once daily administration of amlodipine increases total exercise time, time to angina onset, and time to 1 mm ST segment depression, and decreases both angina attack frequency and nitroglycerine tablet consumption in patients with angi Baca dokumen lengkap