Cobalmin 0.5mg Film-Coated Tablet

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Mecobalamin

Boleh didapati daripada:

Advance Pharma Sdn Bhd

INN (Nama Antarabangsa):

Mecobalamin

Unit dalam pakej:

90 Tablets; 500 Tablets

Dikeluarkan oleh:

AV MANUFACTURING SDN.BHD

Ciri produk

COBALMIN 0.5MG FILM-COATED TABLET
Composition: Each film coated tablet contains mecobalamin 0.5 mg
PRODUCT DESCRIPTION: A round, white film-coated tablet.
PHARMACODYNAMICS
(1) Mecobalamin is a kind of endogenous coenzyme B12:
As a coenzyme of methionine synthetase, mecobalamin plays an important
role in transmethylation in
the synthesis of methionine from homocysteine.
(2) Mecobalamin is well transported to nerve cell organelles, and
promotes nucleic acid and protein
synthesis:
Experiments in rats show that mecobalamin is better transported to
nerve cell organelles than
cyanocobalamin and promotes nucleic acid and protein synthesis more
than cobamamide does. Experiments
with cells from the brain origin and spinal nerve cells in rats also
show mecobalamin to be
involved in the synthesis of thymidine from deoxyuridine, promotion of
deposited folic acid utilization and
metabolism of nucleic acid.
(3) Mecobalamin promotes axonal transport and axonal regeneration:
In rat models with streptozotocin-induced diabetes mellitus,
mecobalamin normalizes axonal
skeletal protein transport in sciatic nerve cells. Mecobalamin
exhibits neuropathologically and
electrophysiologically inhibitory effects on nerve degeneration in
neuropathies induced by drugs, such as
adriamycin, acrylamide, and vincristine (in rats and rabbits), models
of axonal degeneration in mice
and neuropathies in rats with spontaneous diabetes mellitus.
(4) Mecobalamin promotes myelination (phospholipid synthesis) :
Mecobalamin promotes the synthesis of lecithin which is the main
constituent of medullary sheath lipid. It
also increases myelination of neurons in rat tissue culture more than
cobamamide does.
(5) Mecobalamin restores delayed synaptic transmission and diminished
neurotransmitters back to normal:
Mecobalamin restores end-plate potential induction early by increasing
nerve fiber excitability in the crushed
sciatic nerve in rats. In addition, mecobalamin normalizes diminished
levels of acetylcholine in brain tissue of
rats fed with a choline-deficient