Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
TERAZOSIN HCL DIHYDRATE
SUNWARD PHARMACEUTICAL SDN. BHD.
TERAZOSIN HCL DIHYDRATE
30 Tablets; 100 Tablets
TAIWAN BIOTECH CO., LTD.
CONMY TABLETS Terazosin Hydrochloride (2mg) 1 _ CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET 1. What Conmy Tablets 2mg is used for 2. How Conmy Tablets 2mg works 3. Before you use Conmy Tablets 2mg 4. How to use Conmy Tablets 2mg 5. While you are using it 6. Side effects 7. Storage and Disposal of Conmy Tablets 2mg 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT CONMY TABLETS 2MG IS USED FOR It is used as treatment to control high blood pressure and to improve urination in men due to enlargement of prostate gland or known as symptomatic benign prostatic hyperplasia (BPH). HOW CONMY TABLETS 2MG WORKS Terazosin hydrochloride relax the muscles in prostate and bladder neck leads to improve- ment in urine flow. BEFORE YOU USE CONMY TABLETS 2MG _- When you must not use it _ Do not take Conmy Tablets 2mg if you:- have heart failure due to mechanical obstruction. are hypersensitivity to Terazosin hydro- chloride or any ingredients listed at the end of this leaflet. _- Before you start to use it _ Talk to your doctor before taking Conmy Tablets 2mg, if you have: low blood pressure _Pregnancy and breastfeeding _ You should check with your doctor if you are pregnant or think you may be pregnant, planning to become pregnant or if you are breastfeeding. The content and effects of Terazosin hydrochloride during breastfeeding are unknown. _Children _ Safety and effectiveness in children have not been determined. _- Taking other medicines _ There are few medicines which may interact with Conmy Tablets 2mg. It is important to tell your doctor or pharmacist about all the medicines that you are taking, including those obtained without doctor’s prescription. You should talk to your doctor or pharmacist if you are taking:- medicines used for pain killer/anti- inflammatory (such as acetaminophen, aspirin, codeine, ibuprofen, indomethacin). medicines contains control of high blood pressure agents (calcium channel blocker such as verapamil Baca dokumen lengkap
CONMY TABLETS 2MG Terazosin hydrochloride dihydrate 2.37mg equivalent to Terazosin 2mg DESCRIPTION It is a orange, round, flat tablet, a " BH “is scored on one side and “S”on the other side. 2 COMPOSITION Each tablet contains Terazosin hydrochloride dihydrate 2.37mg equivalent to Terazosin 2mg. MODE OF ACTION _BENIGN PROSTATIC HYPERPLASIA (BPH):_ The symptoms associated with BPH are related to bladder outlet obstruction, which is comprised of two underlying components: a static component and a dynamic component. The static component is a consequence of an increase in prostate size. Over time, the prostate will continue to enlarge. However, clinical studies have demonstrated that the size of the prostate does not correlate with the severity of BPH symptoms or the degree of urinary obstruction. The dynamic component is a function of an increase in smooth muscle tone in the prostate and bladder neck, leading to constriction of the bladder outlet. Smooth muscle tone is mediated by sympathetic nervous stimula- tion of alpha-l adrenoceptors, which are abundant in the prostate, prostatic capsule and bladder neck. The reduction in symptoms and improvement in urine flow rates following administration of terazosin is related to relaxation of smooth muscle produced by blockade of alpha-l adrenoceptors in the bladder neck and prostate. Because there are relatively few alpha-l adrenoceptors in the bladder body, terazosin is able to reduce the bladder outlet obstruction without affecting bladder contractility. SUMMARY OF PHARMACODYNAMICS AND PHARMACOKINETICS Terazosin is rapidly and almost completely absorbed from the gastro-intestinal tract after oral administration; the bioavailability is reported to be about 90%. It is metabolized in the liver; one of the metabolites is report to posses antihypertensive activity. The half-life in plasma is approximately 12 hours. It is excreted in faeces via the bile and in the urine, as unchanged drug and metabolites. Terazosin is to 90 to 94% protein bound. INDICATIONS Terazosin hyd Baca dokumen lengkap