DIABETMIN RETARD TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

METFORMIN HYDROCHLORIDE

Boleh didapati daripada:

HOVID BERHAD

INN (Nama Antarabangsa):

METFORMIN HYDROCHLORIDE

Unit dalam pakej:

100 Tablets; 10 x 10's Tablets

Dikeluarkan oleh:

HOVID BERHAD

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
DIABETMIN
_ _
DIABETMIN 250 MG TABLET, DIABETMIN 500 MG TABLET, DIABETMIN RETARD
TABLET, DIABETMIN 850 MG TABLET, DIABETMIN
XR 500 MG TABLET, DIABETMIN 1000 MG TABLET
1
WHAT IS IN THIS LEAFLET?
1.
What Diabetmin is used for
2.
How Diabetmin works
3.
Before you use Diabetmin
4.
How to use Diabetmin
5.
While you are using Diabetmin
6.
Side effects
7.
Storage and Disposal of Diabetmin
8.
Product description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT DIABETMIN IS USED FOR
Used to treat type 2 diabetes or non-
insulin
dependent
diabetes
mellitus
(NIDDM) in adults whose high blood
sugar levels cannot be lowered through
exercising or monitoring food intake.
HOW DIABETMIN WORKS
This medicine belongs to a group called
biguanides that lowers the high blood
sugar levels in the body.
It works by:
•
reducing the amount of blood sugar
produced in the liver
•
improving
your
body’s
sensitivity
towards
insulin
and
the
way
the
body uses insulin
•
slowing down the rate of glucose
being absorbed in the intestines.
BEFORE YOU USE DIABETMIN
_- When you must not use it _
Do not take this medicine if:
•
you are allergic to meformin, any
other biguanide, or its excipients
•
you
have
diabetic
coma
(when
your
blood
sugar
is
abnormally
high
and
body
is
severely
dehydrated)
•
you
have
severe
burns
and
infections
•
you have severely reduced kidney
function
•
you have liver problems
•
you
have
undergone/are
undergoing major surgery
•
you have severe trauma
•
you have lactic acidosis [too much
lactic acid in the blood (see “Risk
of
lactic
acidosis”
below)]
or
ketoacidosis.
Ketoacidosis
is
a
condition
in
which
substances
called ‘ketone bodies’ accumulate
in the blood and which can lead to
diabetic
pre-coma.
Symptoms
of
acidosis may include stomach pain,
abnormal breathing and drowsiness
(if severe).
•
you
have
severe
breathing
difficulties
•
you
have
heart
or
blood
vessel
problems
eg.
heart
failure,
heart
attack,
sudden/rapid
deve

Ciri produk

DIABETMIN TABLET
VIDIA17-var4 (MY)
595
DESCRIPTION
DIABETMIN 500MG TABLET:
Round,
white
film-coated
tablet,
bevel-edged
and
shallow convex faces with deep score line on one side.
DIABETMIN RETARD TABLET:
Round, white uncoated tablet with convex faces.
DIABETMIN 850MG TABLET:
Round, white film-coated tablet with deep convex faces
and 'hovid' embossed on one face.
DIABETMIN 1000MG TABLET:
Oblong, white film-coated tablet, deep convex faces,
deep scored and "HD" embossed on one face and
scored on the other face.
COMPOSITION
DIABETMIN 500MG TABLET:
Metformin Hydrochloride 500mg per tablet.
DIABETMIN RETARD TABLET:
Metformin Hydrochloride 850mg per tablet (Extended-release).
DIABETMIN 850MG TABLET:
Metformin Hydrochloride 850mg per tablet.
DIABETMIN 1000MG TABLET:
Metformin Hydrochloride 1000mg per tablet.
ACTIONS AND PHARMACOLOGY
Metformin is an oral biguanide antidiabetic agent. Its
mode of action is thought to be multifactorial and includes
delayed uptake of glucose from the gastro-intestinal tract;
increased
peripheral
glucose
utilization
mediated
by
increased insulin sensitivity; and inhibition of increased
hepatic and renal gluconeogenesis.
PHARMACOKINETICS
Metformin Hydrochloride is slowly and incompletely
absorbed from the gastrointestinal tract. The absolute
bioavailability of a single 500mg dose is reported to be
about 50 to 60%, although this is reduced somewhat if
taken with food. Plasma protein binding is negligible. It
is
excreted
unchanged
in
the
urine.
The
plasma
elimination half-life is reported to range from about 2 to
6 hours after oral administration.
INDICATIONS
Metformin
is
used
in
the
treatment
of
non-insulin-dependent diabetes mellitus (type 2) in adults,
not
responding
to
exercise
and
dietary
modification.
Diabetmin may be used as monotherapy or in combination
with other oral antidiabetic agents, or with insulin.
CONTRAINDICATIONS
This medication is contraindicated in patients with the
following medical problems:
•
Hypersensitivity to metformin.
•
Any condition needing close blood glucose