Country: Afrika Selatan
Bahasa: Inggeris
Sumber: South African Health Products Regulatory Authority (SAHPRA)
Lennon
INDICATIONS [/za_1260.html#1] [/za_1260.html#1] [/za_1260.html#1] CONTRA-INDICATIONS [/za_1260.html#1] [/za_1260.html#1] DOSAGE [/za_1260.html#1] [/za_1260.html#1] SIDE-EFFECTS [/za_1260.html#1] [/za_1260.html#1] [/za_1260.html#1] PREGNANCY [/za_1260.html#1] [/za_1260.html#1] OVERDOSE [/za_1260.html#1] IDENTIFICATION [/za_1260.html#1] [/za_1260.html#1] PATIENT INFORMATION HY-PO-TONE® 250 HY-PO-TONE® 500 SCHEDULING STATUS: S3 PROPRIETARY NAME (and dosage form): HY-PO-TONE ® 250 HY-PO-TONE ® 500 COMPOSITION: Each tablet contains 250 mg or 500 mg anhydrous METHYLDOPA . PHARMACOLOGICAL CLASSIFICATION: A 7.1 3 Other hypotensives. PHARMACOLOGICAL ACTION: The exact mechanism of pharmacological action is not known. It may involve stimulation of central alpha-adrenergic receptors by a metabolite, alpha-methylnorepinephrine, thus inhibiting sympathetic outflow to the heart, kidneys and peripheral vasculature. Reduced peripheral resistance and plasma renin activity may also contribute to its effect. INDICATIONS: Methyldopa is indicated in the treatment of essential hypertension. CONTRA-INDICATIONS: Methyldopa is contra-indicated in persons known to be sensitive to it. It should be used with caution in patients with impaired kidney or liver function or with a history of liver disease or mental depression. It should not be given to patients with acute liver disease or phaeochromocytoma. It is contra-indicated during pregnancy. Methyldopa has been reported to aggravate porphyria. DOSAGE AND DIRECTIONS FOR USE: Doses of 0,25 g two or three times daily during the first 48 hours. Thereafter, the daily dosage may be adjusted preferably at intervals of not less than 48 hours, until an adequate response has been achieved. The usual dose is from 0,5 g –2 g daily. A suggested Baca dokumen lengkap