MIZOSIN TABLET 2MG

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

SIGMA-PRAZOSIN HYDROCHLORIDE

Boleh didapati daripada:

DUOPHARMA (M) SDN. BHD.

INN (Nama Antarabangsa):

SIGMA-PRAZOSIN HYDROCHLORIDE

Unit dalam pakej:

1000 Tablets; 500 Tablets; 10 x 10 Tablets

Dikeluarkan oleh:

DUOPHARMA (M) SDN. BHD.

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
_ _
MIZOSIN TABLET
Prazosin Hydrochloride
_ _
1
WHAT IS IN THIS LEAFLET
1.
What MIZOSIN TABLET
is used for
2.
How
MIZOSIN
TABLET
works
3.
Before you use MIZOSIN
TABLET
4.
How
to
use
MIZOSIN
TABLET
5.
While
you
are
using
MIZOSIN TABLET
6.
Side effects
7.
Storage
and
disposal
of
MIZOSIN TABLET
8.
Product description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT
MIZOSIN TABLET IS
USED FOR
MIZOSIN TABLET is used to
treat hypertension (high blood
pressure),
benign
prostatic
hyperplasia or BPH (‘prostrate
trouble’)
in
men
waiting
for
prostate
surgery,
raynaud’s
disease,
where
the
fingers
become with and painful when
cold.
HOW
MIZOSIN
TABLET
WORKS
MIZOSIN TABLET consists of
active
substance
Prazosin
Hydrohcloride.
MIZOSIN belongs to a family
of
medicines
called
alpha
blockers.
These
medicines
work by relaxing muscles in the
walls
of
blood
vessels
and
reducing the resistance to blood
flow. They also relieve prostate
problems by relaxing muscles
in
the
prostate
gland
and
increasing the flow of urine.
BEFORE
YOU
USE
MIZOSIN
TABLET
_-_
_ _
_When you must not use it _
Do not use MIZOSIN TABLET
if
you
have
had
any
of
the
following
medical
conditions
unless
advised
otherwise
by
your doctor:
•
If you are hypersensitive to,
or
have
had
an
allergic
reaction to prazosin and any
other
ingredients
in
this
medicine.
_-_
_ _
_Before you start to use it _
Before
taking
MIZOSIN
TABLET, you must tell your
doctor
or
pharmacist
if
you
have, or have had, any of the
following conditions:
•
You have are pregnant or
breasfeeding
or
plan
to
become
pregnant
or
breastfeed.
•
You
have
heart
problems
such
as
heart
failure
or
angina
•
You have kidney or liver
problems
_Pregnancy _
PRAZOSIN IS NOT RECOMMENDED
FOR USE IN PREGNANCY.
_-_
_ _
_Taking other medicines _
Inform
your
doctor
or
pharmacist
before
taking
MIZOSIN TABLET.
Before
using
MIZOSIN
TABLET, it is important to tell
your doctor or pharmacist if you
are taking any other medicines,
obtained
with
or

Ciri produk

[DUOPHARMA (M) SDN BHD]
[Page 1/2]
[Revision date: (03.09.2020)]
MIZOSIN TABLET
DESCRIPTION:
MIZOSIN TABLET 1MG: An orange, 7 mm round, biconvex, with ‘1’
scored on one side and plain on the other side, uncoated tablet.
MIZOSIN TABLET 2MG: A white, 8 mm round, biconvex, with ‘2’ scored
on one side and plain on the other side, uncoated tablet.
COMPOSITION:
MIZOSIN TABLET 1MG: Each tablet contains (Sigma) Prazosin
Hydrochloride equivalent to Prazosin 1 mg.
MIZOSIN TABLET 2MG: Each tablet contains (Sigma) Prazosin
Hydrochloride equivalent to Prazosin 2 mg.
PHARMACODYNAMICS:
Prazosin HCl causes a decrease in total peripheral resistance but the
exact mechanism of action is unknown. Animal studies suggest that the
vasodilator effect of Prazosin HCl is related to the blockade of post-
synaptic alpha-adreno-receptors. The results of dog forelimb
experiments demonstrate that the peripheral vasodilator effect is
confined mainly to the level of the resistance vessels (arterioles).
Unlike conventional
alpha-blockers the antihypertensive action of Prazosin HCl is usually
not accompanied by reflex tachycardia. Haemodynamic studies have been
carried out in hypertensive patients following acute single dose
administration and during the course of long-term maintenance therapy.
The results confirm that the usual therapeutic effect is a fall in
blood pressure unaccompanied by a clinically significant change in
cardiac
output, heart rate, renal blood flow, and glomerular filtration rate.
There is no measurable negative chronotropic effect.
Prazosin HCl may increase plasma renin activity in patients with
congestive cardiac failure.
Clinically, the antihypertensive effect is believed to be a direct
result of peripheral vasodilation. In man, blood pressure is lowered
in both the supine and standing positions. This effect is more
pronounced on the
diastolic blood pressure. Tolerance does not appear to develop in
long-term clinical use in the treatment of hypertension. Rebound
elevation of blood pressure does not occur following