MUODERM (Mupirocin 2%ww Ointment)

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

MUPIROCIN

Boleh didapati daripada:

HEALOL PHARMACEUTICALS SDN. BHD.

INN (Nama Antarabangsa):

MUPIROCIN

Unit dalam pakej:

15 gm

Dikeluarkan oleh:

ICPA Health Products Limited,

Risalah maklumat

MUODERM
_ Medication Information Leaflet (RiMUP)_
Mupirocin 2%w/w Ointment
1
WHAT IS IN THIS LEAFLET
1.
What Muoderm Ointment is used
for
2.
How Muoderm Ointment works
3.
Before
you
use
Muoderm
Ointment
4.
How to use Muoderm Ointment
5.
While you are using it
6.
Side effects
7.
Storage
and
Disposal
of
Muoderm Ointment
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
11.
Serial number
WHAT IS MUODERM OINTMENT USED
FOR
Muoderm
(simply
called
Muoderm
Ointment throughout the rest of this
leaflet) is an antibiotic. It is used to
kill bacteria in skin infections such as
impetigo
(which
may
appear
as
a
small
scratch
or
itchy
patch
of
eczema), folliculitis (swelling of the
skin around the hair roots) and boils.
Muoderm Ointment is for external use
on your skin only.
HOW MUODERM OINTMENT WORKS
Muoderm
(simply
called
Muoderm
Ointment throughout the rest of this
leaflet) is an antibiotic. It is used to
kill bacteria in skin infections such as
impetigo
(which
may
appear
as
a
small
scratch
or
itchy
patch
of
eczema), folliculitis (swelling of the
skin around the hair roots) and boils.
Muoderm Ointment is for external use
on your skin only.
BEFORE YOU USE MUODERM OINTMENT
_-When you must not use it _
Before you use Muoderm Ointment
• if you are allergic to Mupirocin or
any of the other ingredients of this
medicine
• to treat infections in your nose
• to treat infections in your eyes
• around intravenous cannula (“drip”)
sites.
Symptoms of an allergic reaction may
include a red and lumpy skin rash,
difficulty breathing, swelling of face,
mouth, lips or eyelids, unexplained
high temperature (fever) and feeling
faint.
If
the
swelling
affects
your
throat
and
makes
breathing
and
swallowing difficult, go to hospital
straight away
_-Before you start to use it _
Talk to your doctor, pharmacist or
nurse
before
using
Muoderm
Ointment
• if you have problems with your
kidneys
•
if
you
have
open
wounds
or
damaged skin.
If you use Muoderm Ointment for a
long period of time, you may d

Ciri produk

For the use of a Registered Medical Practitioner or Hospital or a
Laboratory.
MUODERM
MUPIROCIN 2%W/W OINTMENT
ACTIVE INGREDIENT:
Mupirocin BP
EXCIPIENT:
Macrogol 400, and Macrogol 3350.
DOSAGE FORM:
Topical Ointment
PRODUCT DESCRIPTION:
White or almost white Ointment.
PHARMACODYNAMICS:
Pharmacotherapeutic group: Antibiotics and chemotherapeutics for
topical use, ATC code: D06AX09
Mechanism of action
Mupirocin is a novel antibiotic produced through fermentation by
Pseudomonas fluorescens. Mupirocin
inhibits isoleucyl transfer-RNA synthetase, thereby arresting
bacterial protein synthesis. Mupirocin has
bacteriostatic properties at minimum inhibitory concentrations and
bactericidal properties at the higher
concentrations reached when applied locally.
Mechanism of Resistance
Low-level resistance in staphylococci is thought to result from point
mutations within the usual
staphylococcal chromosomal gene (ileS) for the target isoleucyl tRNA
synthetase enzyme. High-level
resistance in staphylococci has been shown to be due to a distinct,
plasmid encoded isoleucyl tRNA
synthetase enzyme. Intrinsic resistance in Gram negative organisms
such as the Enterobacteriaceae
could be due to poor penetration of the outer membrane of the
Gram-negative bacterial cell wall.Due to
its particular mode of action, and its unique chemical structure,
mupirocin does not show any cross-
resistance with other clinically available antibiotics.
Microbiological Susceptibility
The prevalence of acquired resistance may vary geographically and with
time for selected species, and
local information on resistance is desirable, particularly when
treating severe infections. As necessary,
expert advice should be sought when the local prevalence of resistance
is such that the utility of the
agent in at least some types of infection is questionable.
PHARMACOKINETICS:
After
topical
application
of
Mupirocin
Ointment,
mupirocin
is
only
very
minimally
absorbed
systemically and that which is absorbed is rapidly metabolised to the
antimicrobially inactive metabol