Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
MUPIROCIN
HOE PHARMACEUTICALS SDN. BHD.
MUPIROCIN
5gm mcg/mL; 15gm mcg/mL
HOE PHARMACEUTICALS SDN. BHD.
DESCRIPTION: A white ointment containing 2.0% w/w Mupirocin. PHARMACODYNAMICS: Mupirocin inhibits bacterial protein synthesis by binding to isoleucyl-transfer RNA synthetase. Due to this particular mode of action and its unique molecular structure, Mupirocin does not show any cross-resistance with other antibiotics. It is mainly active against Gram-positive aerobes, most strains of staphylococci including methicillin-resistant and multiple resistant staphylococcus aureus and streptococci. lt is also active against some Gram-negative bacterium. PHARMACOKINETICS: Mupirocin is rapidly inactivated after absorption and its systemic level is undetectable. Virtually no systemic absorption ( < 1.1 nanograms per mL of whole blood ) following application to lower arm of normal males with occlusion for 24 hours. INDICATIONS: Bacterial skin infections. CONTRAINDICATIONS: Hypersensitivity to Mupirocin, polyethylene glycol or any other constituent in the ointment base. DRUG INTERACTIONS: Unknown. ADVERSE EFFECTS: Mupirocin is usually well tolerated but local reactions such as burning, stinging and itching may occur after the application of Mupirocin to the skin. Muprin Ointment has not been reported to cause contact sensitization or photosensitivity reactions. The polyethylene glycol vehicle in Muprin Ointment may irritate broken skin or mucous membranes. Muprin Ointment may cause some unwanted effects. The following side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of these persist or are bothersome. Less frequently reported unwanted effects include dry skin; skin burning, itching, pain, rash, redness, stinging or swelling; headache; nausea. Rarely reported are abdominal pain; dizziness; secondary wound infection; ulcerative stomatitis ( sores in mouth or on lips ). PRECAUTIONS/WARNINGS: Not for ophthalmic or intranasal use. Avoid contact with eyes: use with caution if there is evidence of moderate or severe renal impairment. Check with physician or pharmaci Baca dokumen lengkap