Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
AMLODIPINE BESILATE
DUOPHARMA (M) SDN. BHD.
AMLODIPINE BESILATE
30tablet Tablets
DUOPHARMA MANUFACTURING (BANGI) SDN BHD
NORDIPINE Page 1 NORDIPINE TABLET 5MG & 10MG _Amlodipine Besylate_ _ 5mg & 10mg_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about NORDIPINE. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking NORDIPINE against the benefits it is expected to have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT NORDIPINE IS USED FOR_____________ NORDIPINE is used to lower high blood pressure (hypertension). There are usually no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems. NORDIPINE is also used to treat angina pectoris. Angina is a pain or uncomfortable feeling in the chest, often spreading to the arms or neck, and sometimes to the shoulders and back. The pain of angina is due to a shortage of oxygen to the heart. NORDIPINE is not for the relief of a sudden attack of angina. Your doctor will give you other medication to treat this. ___________________________ HOW NORDIPINE WORKS NORDIPINE belongs to a group of medicines called _ calcium channel _ _blockers _or _calcium ion antagonists. _ They work by widening your blood vessels, making it easier for your heart to pump blood around the body and help increase the supply of blood and oxygen to your heart. _Calcium channel blockers _do not change the amount of calcium in your blood or bones. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY NORDIPINE HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. This medicine is available only with a doctor's prescription. _USE IN CHILDREN_ There is not enough information to recommend the use of this medicine in children. BEFO Baca dokumen lengkap
Nordipine (Amlodipine Besylate) Revision date: 9 June 2021 DESCRIPTION & COMPOSITION Nordipine Tablet 5mg White to off-white, shield shape tablet, marked ‘COV’ on one side and scored on the other side. Nordipine Tablet 10mg White to off-white, shield shape tablet, marked ‘COV’ on one side and marked ‘10’ with scored line on the other side. PHARMACEUTICAL FORM/ROUTE OF ADMINISTRATION Tablet/Oral. PHARMACODYNAMIC Amlodipine is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into the cardiac and vascular smooth muscle. The mechanism of the antihypertensive action of amlodipine is due to a direct relaxant effect on the vascular smooth muscle. The precise mechanism by which amlodipine relieves angina has not been fully determined, but amlodipine reduces the total ischemic burden by the following 2 actions: - Amlodipine dilates the peripheral arterioles and thus, reduces the total peripheral resistance (after load) against which the heart works. Since the heart rate remains stable, this unloading of the heart reduces myocardial energy consumption and oxygen requirements. - The mechanism of action of amlodipine probably involves dilatation of the main coronary arteries and coronary arterioles, both in normal and ischemic regions. This dilatation increases myocardial oxygen delivery in patients with coronary artery spasm (Prinzmetal's or variant angina) and blunts smoking induced coronary vasoconstriction. In patients with hypertension, once daily dosing provides clinically significant reductions of blood pressure in both the supine and standing positions throughout the 24 hours interval. Due to the slow onset of action, acute hypotension is not a feature of amlodipine administration. In patients with angina, once daily administration o f amlodipine increases total exercise time, time to angina onset, and time to 1mm ST segment depression, and decreases both angina attack frequency and nitroglycerine tablet consumption. In v Baca dokumen lengkap