RICAM SYRUP 5mg5ml

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

CETIRIZINE HYDROCHLORIDE

Boleh didapati daripada:

HOVID BERHAD

INN (Nama Antarabangsa):

CETIRIZINE HYDROCHLORIDE

Unit dalam pakej:

120ml ml; 60ml ml; 30ml ml; 30ml ml; 30 ml; 60 ml; 120 ml

Dikeluarkan oleh:

HOVID BERHAD

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
RICAM SYRUP 5MG/5ML
Cetirizine Hydrochloride (5mg/5mL)
1
WHAT IS IN THIS LEAFLET
1.
What Ricam is used for
2.
How Ricam works
3.
Before you use Ricam
4.
How to use Ricam
5.
While you are using Ricam
6.
Side effects
7.
Storage and Disposal of Ricam
8.
Product description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT RICAM IS USED FOR
It
is
used
to
treat
nose
mucous
membrane
inflammation
symptoms
(due to seasonal or long term allergy)
and rashes of allergic origin, for adults
and children of 2 years and above.
HOW RICAM WORKS
This
medicine
belongs
to
a
group
known as antihistamines, which act to
relieve
the
symptoms
of
allergies.
It
works by competing with histamine for
H1–receptor
sites,
thereby
preventing
the action of histamine on the cell.
Cetirizine may also have a modulatory
effect
on
inflammatory
cells
by
inhibiting
eosinophil
migration
or
eosinophilotactic
mediators
and
other
infiltrating inflammatory cells, such as
neutrophils.
BEFORE YOU USE RICAM
_- When you must not use it _
_ _
Do not take this medicine if:
•
you are allergic to antihistamines or
any of the ingredients listed at the
end of this leaflet.
•
you have severe kidney failure
•
You
have
problems
of
urinary
retention
If you are not sure whether you should
start taking this medicine, talk to your
pharmacist or doctor.
_- Before you start to use it _
_ _
Tell your doctor/pharmacist if:
•
you
have
problems
with
your
kidneys
•
you
are
pregnant,
think
you
are
pregnant
or
plan
to
become
pregnant
•
you
are
breastfeeding
or
plan
to
breastfeed
•
you suffer from epilepsy or are at
risk of convulsions
_- Taking other medicines _
_ _
Tell your doctor or pharmacist before
taking Ricam if you are taking any other
medicines, including any that you buy
without a prescription from pharmacy,
supermarket or health food shop. The
effects
of
some
medicines
may
be
affected if other medicines are used at
the same time.
Other interactions not stated may occur.
Talk to your

Ciri produk

VIRIC14-var1 (MY)
RICAM SYRUP
5 MG / 5 ML
DESCRIPTION
Clear colourless syrup with Tutti-Frutti flavour.
COMPOSITION
Cetirizine hydrochloride 5 mg / 5 mL.
PHARMACODYNAMICS
Cetirizine hydrochloride, a human metabolite of hydroxyzine,
is a potent antihistamine that selectively inhibits the effect of
peripheral H1-receptors.
Cetirizine belongs to the piperazine class of antihistamines
and is the major carboxylated metabolite of hydroxyzine.
However, it is less lipophilic than hydroxyzine and thus less
likely to distribute into the central nervous system (CNS) and
produce sedation.
Generally, antihistamines contain 1 or 2 heterocyclic or
aromatic rings attached to the side chain of histamine.
Cetirizine has more polar or less lipophilic functional groups
attached to the ethylamine side chain which has resulted in
less CNS penetration, greater selectivity for the H1-receptor,
and less anticholinergic side effects.
Cetirizine
may
also
have
a
modulatory
effect
on
inflammatory
cells
by
inhibiting
eosinophil
migration
or
eosinophilotactic mediators. Additionally, cetirizine may also
have inhibitory effects on other infiltrating inflammatory cells,
such as neutrophils.
Cetirizine has shown to be safe for allergic patients with mild
to moderate asthma and does not cause prolongation of QT
interval.
PHARMACOKINETICS
ABSORPTION
Cetirizine is rapidly absorbed from the gastrointestinal tract
after oral doses and peak plasma concentrations occur
within about an hour. Food delays the time to peak plasma
concentrations but does not decrease the amount of drug
absorbed.
BIOAVAILABILITY
Oral: 70%.
The extent of bioavailability is similar when cetirizine is given
as solutions, capsules or tablets.
DISTRIBUTION
Cetirizine is highly bound to plasma proteins (93%). Volume
of distribution is 0.5 to 0.8 L/kg.
It does not appear to cross the blood-brain barrier to a
significant extent. It has been detected in breast milk.
METABOLISM
Cetirizine is not extensively metabolized by the liver. The
inactive O-dealkylated metabolite has been identi