SALCODYL SYRUP

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

SALBUTAMOL SULPHATE; GUAIPHENESIN/GUAICOL GLYCEROL ETHER

Boleh didapati daripada:

DYNAPHARM (M) SDN BHD

INN (Nama Antarabangsa):

SALBUTAMOL SULPHATE; GUAIPHENESIN/GUAICOL GLYCEROL ETHER

Unit dalam pakej:

100 ml mL; 120ml mL

Dikeluarkan oleh:

DYNAPHARM (M) SDN BHD

Ciri produk

SALCODYL SYRUP
MAL19950247AZ
DESCRIPTION:
SYRUP
Colour
: Red
Flavour
: Rose
CONTENT:
Each 5 ml contains:
Salbutamol Sulphate equivalent to Salbutamol ............ 1 mg
Guaiphenesin ................................................... 50 mg
Preservatives
: Methyl Paraben 0.15% w/v &
Propyl Paraben 0.02% w/v.
Colouring Agent
: Raspberry Red
Flavouring Agent : Rose
PHARMACODYNAMICS:
Salbutamol is a directly acting sympathomimetic amine. Its main action
is on the adrenergic receptors in the bronchi and the
respiratory tract rather than on the cardiac receptor. For this reason
it induces bronchodilation and inhibits bronchospasm in
doses which do not produce marked cardiac acceleration.
Guaiphenesin has an expectorant action which increases the output of
respiratory tract fluid by reducing adhesiveness and
surface tension. The increase flow of less viscid secretions promotes
ciliary action and facilitates the removal of mucus. This
changes a dry unproductive cough to a cough that is more productive
and less frequent.
PHARMACOKINETICS:
Salbutamol is rapidly absorbed after oral administration. After an
oral dose of 4 to 8 mg, peak plasma concentrations of about
23 ng/ml for unchanged drug and 50 to 100 ng/ml for unchanged drug
plus metabolite are attained in 2.5 to 3 hour. Plasma half-
life is 2 to 7 hour. Salbutamol is metabolised by first pass
metabolism, the reactions and metabolites involved are not yet
identified. About 75 to 95% of an oral dose is excreted in the urine
and about 4% in the faeces in 3 days. Following oral
administration, 50 to 60% of the urinary excreted material is
metabolised.
Guaiphenesin is readily absorbed from gastrointestinal tract. It is
rapidly metabolised and excreted in the urine.
INDICATION:
Relief of productive and wheezing cough associated with pneumonia,
influenza and acute respiratory infections.
RECOMMENDED DOSE:
Adults
:
2 to 4 teaspoonfuls (10 ml – 20 ml) 2 to 3 times daily.
Children 2-6 years
:
1 to 2 teaspoonfuls (5 ml – 10 ml) 2 to 3 times daily.
6-12 years :
2 teaspoonfuls