Country: Amerika Syarikat
Bahasa: Inggeris
Sumber: NLM (National Library of Medicine)
SODIUM BICARBONATE (UNII: 8MDF5V39QO) (BICARBONATE ION - UNII:HN1ZRA3Q20)
Cardinal Health
INTRAVENOUS
PRESCRIPTION DRUG
Sodium Bicarbonate Injection, USP is indicated in the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Sodium bicarbonate is further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturate-protein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments. Sodium bicarbonate also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Treatment of metabolic acidosis should, if possible, be superimposed on measures designed to control the basic cause of the acidosis ― e.g., insulin in uncomplicated diabetes, blood volume restoration in shock. But since an appreciable time interval may elapse before
Sodium Bicarbonate Injection, USP is supplied in the following dosage forms: List No. Dosage Form Conc. % mg/mL (NaHCO3 ) mEq/mL (Na+ ) mEq/mL (HCO3 ― ) mEq/Container size (mL) mOsmol pH 6637 6625 4900 4916 1594 5534 Abboject® Syringe Fliptop Vial Abboject® Syringe (Pediatric) Abboject® Syringe LVP Glass Container Abboject® Syringe (Infant) 8.4 8.4 8.4 7.5 5.0 4.2 84 84 84 75 50 42 1.0 1.0 1.0 0.9 0.6 0.5 1.0 1.0 1.0 0.9 0.6 0.5 50/50 50/50 10/10 44.6/50 297.5/500 5/10 2/mL 2/mL 2/mL 1.79/mL 1190/liter 1/mL 8.0 (7.0 to 8.5) 7.8 (7.0 to 8.5) 8.0 (7.0 to 8.5) 8.0 (7.0 to 8.5) 7.8 (7.0 to 8.5) 8.0 (7.0 to 8.5) Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Revised: October, 2005 ©Hospira 2005 EN-1064 Printed in USA HOSPIRA, INC., LAKE FOREST, IL 60045 USA ABBOJECT® is a trademark of the Abbott group of companies.
unapproved drug other
SODIUM BICARBONATE- SODIUM BICARBONATE INJECTION, SOLUTION CARDINAL HEALTH _Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been_ _approved by FDA. For further information about unapproved drugs, click here._ ---------- SODIUM BICARBONATE INJECTION, USP FOR CORRECTION OF METABOLIC ACIDOSIS AND OTHER CONDITIONS REQUIRING SYSTEMIC ALKALINIZATION. ABBOJECT SYRINGE LVP GLASS CONTAINER FLIPTOP VIAL R only DESCRIPTION Sodium Bicarbonate Injection, USP is a sterile, nonpyrogenic, hypertonic solution of sodium bicarbonate (NaHCO ) in water for injection for administration by the intravenous route as an electrolyte replenisher and systemic alkalizer. Solutions are offered in concentrations of 4.2%, 5.0%, 7.5% and 8.4%. See table in HOW SUPPLIED section for contents and characteristics. Solution in LVP container has 0.9 mg/mL of edetate disodium, anhydrous added as a stabilizer. The solutions contain no bacteriostat, antimicrobial agent or added buffer and are intended only for use as a single-dose injection. When smaller doses are required, the unused portion should be discarded with the entire unit. Sodium bicarbonate, 84 mg is equal to one milliequivalent each of Na and HCO ¯. Sodium Bicarbonate, USP is chemically designated NaHCO , a white crystalline powder soluble in water. Water for Injection, USP is chemically designated H O. CLINICAL PHARMACOLOGY Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis. Sodium bicarbonate in water dissociates to provide sodium (Na ) and bicarbonate (HCO ¯) ions. Sodium (Na ) is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Bicarbonate (HCO ¯) is a normal constituent of body fluids and the normal plasma level ranges from 24 to 31 mEq/liter. Plasma concentration is regulated by the kidney through acidification of the urine when t Baca dokumen lengkap